Optimizing Outcomes in Hypoparathyroidism: A New Era in Treatment Approaches

Welcome back to another HCPLive Peer Exchange series. In this opening episode, panelists highlight the underlying causes of hypoparathyroidism and the impact of the loss of parathyroid hormone function by examining the following critical questions: 1. What is chronic hypoparathyroidism, and how is it defined? 2. How does the loss of parathyroid hormone (PTH) function disrupt calcium and phosphate homeostasis in hypoparathyroidism? 3. What are the causes of chronic hypoparathyroidism, and is there any way to predict or prevent it? When might genetic testing be appropriate? In the next episode, panelists will continue their discussion on hypoparathyroidism and highlight how it is diagnosed and the key challenges in the diagnosis and monitoring of patients with hypoparathyroidism.

In this episode, ‘Hypoparathyroidism Diagnosis and Challenges,’ the panelists explore how hypoparathyroidism is diagnosed as well as key diagnostic and monitoring challenges that clinicians face. Led by the moderator, Dr. Kohlmeier, the expert panel, Dr. Rubin, Dr. Warren, and Dr. Al-Dallal, examines the following critical questions: 1. How is hypoparathyroidism diagnosed? 2. What are the key challenges in both diagnosing and monitoring patients with hypoparathyroidism? Throughout the conversation, the experts provide a comprehensive reflection on the field and the factors that may shape how clinicians approach care moving forward. The next episode in this series, ‘Acute and Long-Term Complications of Hypoparathyroidism,’ features the panelists advancing their conversation on hypoparathyroidism and focusing on the potential renal, neuromuscular, cognitive, and bone complications that impact patients.

In ‘Acute and Long-Term Complications of Hypoparathyroidism,’ our panel delves into the potential renal, neuromuscular, cognitive, and bone complications that impact patients. Led by the moderator, Dr. Kohlmeier, the expert panel, Dr. Rubin, Dr. Warren, and Dr. Al-Dallal, examines the following critical questions: 1. How is hypoparathyroidism diagnosed? 2. What are the key challenges in both diagnosing and monitoring patients with hypoparathyroidism? Throughout the conversation, the experts provide a comprehensive reflection on the field and the factors that may shape how clinicians approach care moving forward. The next episode in this series, ‘Acute and Long-Term Complications of Hypoparathyroidism,’ features the panelists advancing their conversation on hypoparathyroidism and focusing on the potential renal, neuromuscular, cognitive, and bone complications that impact patients.

In ‘Acute and Long-Term Complications of Hypoparathyroidism,’ our panel delves into the potential renal, neuromuscular, cognitive, and bone complications that impact patients.

In this episode, ‘Challenges of Conventional Therapy in Hypoparathyroidism,’ the expert endocrinologists explore conventional therapy for chronic hypoparathyroidism, symptom control, and the risk of complications.

In ‘Novel Approaches in Hypoparathyroidism Management,’ our experts delve into novel treatment options for patients who are inadequately controlled on conventional therapy and the mechanism of action of palopegteriparatide.

This episode, titled ‘Evaluating the Efficacy and Safety of Palopegteriparatide in Hypoparathyroidism from the PaTHway Trial,’ features panelists discussing the efficacy and safety data of palopegteriparatide in hypoparathyroidism from the phase 3 PaTHway trial as well as the limitations of the trial.

In this episode, ‘Addressing Bone Health in the Management of Hypoparathyroidism,’ the experts explore approaches to managing hypoparathyroidism in patients with osteoporosis.

In ‘Safety and Titration Considerations and Quality of Life Impact of PTH-Based Therapy in Hypoparathyroidism,’ our panel delves into the potential titration challenges, safety considerations, and long-term monitoring of PTH-based therapy in patients with hypoparathyroidism. They also discuss the impact of PTH-based therapy on patient quality of life.

This episode, titled ‘Multidisciplinary Approaches to Hypoparathyroidism Management,’ features expert endocrinologists discussing the role of multidisciplinary collaboration among endocrinologists, nephrologists, and primary care providers.

In this episode, ‘Value of Medical Advocates for Patients and Educational Resources for Clinicians in Hypoparathyroidism,’ the experts explore the importance of recommending medical advocates or medical alerts to patients as well as educational resources that are available for community providers to better manage hypoparathyroidism.

In ‘Emerging Therapies in Hypoparathyroidism,’ our experts delve into three emerging therapies in chronic hypoparathyroidism.

In the final episode, ‘Closing Thoughts on Hypoparathyroidism Management,’ the panelists share their key takeaways from the series discussion on hypoparathyroidism.