Experts explore why FCS remains one of the most emotionally and clinically challenging lipid disorders despite decades of management effort.

Understand how to systematically exclude secondary causes and identify FCS in patients presenting with severe hypertriglyceridemia and recurrent pancreatitis.

Discover how heterozygous LPL variants, polygenic contributors, and multifactorial presentations complicate FCS classification and the implications for clinical recognition.

Explore how the North American FCS score enables clinical diagnosis when genetic testing is unavailable, and why gastroenterologists remain an undertapped referral source.

Understand the evidence base for LPL-targeted treatment strategies in FCS, when to discontinue ineffective agents, and how to assess atherosclerosis risk in this population.

Explore plasma exchange as a management strategy for FCS in pregnancy and the clinical red flags that should prompt referral to a lipid specialist.