ACC 2025 Recap: 10 Trials to Know

The American College of Cardiology (ACC) 2025 Scientific Sessions showcased multiple clinical trials that could reshape cardiovascular care. This year’s presentations spanned a diverse range of topics, from novel pharmacologic interventions to procedural advancements, offering critical insights into the management of heart failure, atherosclerosis, ischemic heart disease, and more. Several highly anticipated trials addressed persistent clinical challenges, such as the use of SGLT2 inhibitors in high-risk populations, the role of siRNA therapies in lipoprotein(a) reduction, and the latest strategies for optimizing antithrombotic therapy.