One year after the FDA approved brensocatib (Brinsupri) as the first disease-modifying therapy for non-cystic fibrosis bronchiectasis, pulmonologists who prescribe it daily describe a field transformed from having no targeted treatment at all to weighing a genuine, if imperfect, first-in-class option.
The August 12, 2025 approval was built on the phase 3 ASPEN trial, the largest study ever conducted in bronchiectasis, enrolling 1721 patients.1 Brensocatib, an oral inhibitor of dipeptidyl peptidase-1 (DPP-1), works...