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This Year In Medicine 2025

Opinion|Videos|November 27, 2024

Severe Hypertriglyceridemia

Author(s)Peter Toth, MD, PhD, FCCP, FESC, FAHA, FACC , James Underberg, MS, MD, FACP, FACPM, FASPC, FASH, FNLA , Erin Michos, MD, MHS, FACC, FAHA, FASE, FASPC

Key Takeaways

Familial chylomicronemia syndrome (FCS) is a genetic disorder causing severe hypertriglyceridemia due to impaired lipoprotein lipase activity.
FCS leads to extremely elevated triglyceride levels, increasing the risk of recurrent pancreatitis and other complications.
Management includes dietary modifications and emerging pharmacological therapies targeting genetic defects to reduce triglyceride levels.

SHOW MORE

Panelists discuss how Familial Chylomicronemia Syndrome (FCS) fits into the context of severe hypertriglyceridemia, highlighting its distinct characteristics and the associated risks of acute pancreatitis.

Episodes in this series

EP. 1 Overview of FCS

EP. 1 Overview of FCS

EP. 2 Severe Hypertriglyceridemia

EP. 2 Severe Hypertriglyceridemia

EP. 3 Pathophysiology of FCS

EP. 3 Pathophysiology of FCS

EP. 4 Genetic Testing

EP. 4 Genetic Testing

EP. 5 Early Diagnosis

EP. 5 Early Diagnosis

EP. 6 Metabolic Disorders and Delayed Diagnosis

EP. 6 Metabolic Disorders and Delayed Diagnosis

EP. 7 FCS’ Affect on Quality of Life

EP. 7 FCS’ Affect on Quality of Life

EP. 8 Multidisciplinary Approach to Managing FCS

EP. 8 Multidisciplinary Approach to Managing FCS

EP. 9 Medium Chain Fatty Acids

EP. 9 Medium Chain Fatty Acids

EP. 10 Specialists’ Individual Treatment Plans for Patients With FCS: PCP

EP. 10 Specialists’ Individual Treatment Plans for Patients With FCS: PCP

EP. 11 Specialists’ Individual Treatment Plans for Patients With FCS: Pancreatic Specialist

EP. 11 Specialists’ Individual Treatment Plans for Patients With FCS: Pancreatic Specialist

EP. 12 Current FCS Standard-of-Care Treatment Recommendations

EP. 12 Current FCS Standard-of-Care Treatment Recommendations

EP. 13 APOC3 Inhibitors

EP. 13 APOC3 Inhibitors

EP. 14 Diet, Exercise, and Other Lifestyle Factors

EP. 14 Diet, Exercise, and Other Lifestyle Factors

EP. 15 FCS Patient Case study

EP. 15 FCS Patient Case study

Video content above is prompted by the following:

How does FCS fit into the context of severe hypertriglyceridemia?

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