In the phase 2b EVIDENCES X trial, saroglitazar 4 mg resolved MASH without worsening fibrosis in 39.1% of patients vs 13.7% with placebo at 52 weeks.
News|Articles|December 17, 2025
The Lancet Commission on Obesity: Redefining Endocrinology’s Most Notorious Condition
Author(s)Ryan Livingston
Fact checked by: Patrick Campbell
Experts redefine obesity, distinguishing between preclinical and clinical forms, aiming to improve diagnosis and treatment strategies for better health outcomes.
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Obesity is a worldwide epidemic, affecting 1 in 8 people worldwide in 2022. Worldwide adult obesity has more than doubled since 1990, with 2.5 billion adults overweight and 890 of these living with obesity in 2022. Additionally, 43% of adults ≥18 years were overweight in 2022, and 16% were living with obesity. In 2024, 35 million children <5 years were overweight.1
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