
Andrew Mastro, MS, PA-C, asks Alexa Hetzel, MS, PA-C, whether efficacy and durability drive first-time systemic treatment decisions or whether route of administration and patient comfort carry more weight in practice.

Andrew Mastro, MS, PA-C, is a board-certified PA and guest lecturer at both Rush University and Northwestern University.

Andrew Mastro, MS, PA-C, asks Alexa Hetzel, MS, PA-C, whether efficacy and durability drive first-time systemic treatment decisions or whether route of administration and patient comfort carry more weight in practice.

Returning after a break in filming, Andrew Mastro, MS, PA-C, asks Alexa Hetzel, MS, PA-C, whether a persistent gap remains in plaque psoriasis care despite the expanding menu of oral and injectable options, whether tied to a specific patient population or to access itself.

Andrew Mastro, MS, PA-C, closes out this stretch of the conversation by asking Alexa Hetzel, MS, PA-C, to look three to five years ahead and describe how she expects the plaque psoriasis treatment paradigm to evolve.

Andrew Mastro, MS, PA-C, widens the lens and asks Alexa Hetzel, MS, PA-C, where icotrokinra sits within the broader plaque psoriasis landscape, including whether route of administration itself shapes patient preference.

Andrew Mastro, MS, PA-C, asks Alexa Hetzel, MS, PA-C, to describe the patient profile she has in mind when reaching for icotrokinra.

The discussion turns to mechanism of action as Andrew Mastro, MS, PA-C, asks Alexa Hetzel, MS, PA-C, where icotrokinra sits conceptually relative to the biologic classes that have anchored psoriasis treatment.

Andrew Mastro, MS, PA-C, turns the conversation to a population clinicians often approach with extra caution, adolescents with plaque psoriasis, asking Alexa Hetzel, MS, PA-C, how icotrokinra's approval in this group and its once-daily dosing affect the treatment conversation.

Andrew Mastro, MS, PA-C, asks Alexa Hetzel, MS, PA-C, to place icotrokinra alongside the oral agents clinicians have relied on to date, apremilast and deucravacitinib.

Trace how oral plaque psoriasis therapy has evolved over time, from PDE4 and TYK2 inhibition to once-daily oral peptides.

Explore why therapeutic inertia keeps plaque psoriasis patients cycling through topicals instead of escalating to systemic therapy.

Explore the long-term safety and efficacy of JAK inhibitors in atopic dermatitis, enhancing patient care and clinician confidence.

Healthcare providers discuss the importance of effective communication when switching patients from biologics to JAK inhibitors.

Clinicians discuss the importance of patient-centered treatment decisions and the need to address therapeutic inertia in managing chronic conditions.

Explore the evolving landscape of atopic dermatitis treatment, focusing on advanced therapies and long-term patient management strategies.

Healthcare professionals explore effective questioning techniques to uncover deeper emotional and physical impacts of skin pain in patients.

This video explores skin pain as a key symptom of atopic dermatitis and reviews clinical trial data with JAK inhibitors.

November 26th 2025