associate professor of medicine, State University of New York at Stony Brook.

Articles by associate professor of medicine, State University of New York at Stony Brook.

Spironolactone and hyperkalemia in congestive heart failure

ByGeorge I. Mallis, MD, is chief of cardiology, Veterans Affairs Medical Center, Northport, New York,associate professor of medicine, State University of New York at Stony Brook.

September 19th 2008

In 1999 Pitt and colleagues published the results of the RALES trial, an important study showing that the addition of a relatively small dose of the aldosterone antagonist spironolactone to a regimen that included angiotensin-converting enzyme (ACE) inhibitors for patients with severe congestive heart failure (NYHA Class III-IV) had a striking benefit on mortality