Daclatasvir-Sofosbuvir-Ribavirin Combination Similar to VEL/SOF Plus RBV for Hepatitis C Genotypes
Treatment regimens comprised of DCV+SOF±RBV and VEL/SOF+RBV offer similar cure rates among HCV patients with genotypes 2 and 3.
VA Corporate Data Proves To Accurate Source for HCV Treatment Assessment
This observational data could serve an important role in pharmacoepidemiologic studies that would assess the overall benefit and risks of modern HCV therapies, namely direct-acting antivirals.
Gastrointestinal Comorbidities Increase Risk of C Difficile for Patients with UTIs
Female sex, previous gastrointestinal, and non-gastrointestinal comorbidities are associated with C difficile infection in women with UTIs, study finds.
Intervention Improves Practices Among Nurses Managing Hospitalized Patients with C Difficile
A face-to-face, case-specific education intervention improved the management practices among nurses who cared for hospitalized patients with C difficile infections.
Quantitative PCR Highly Sensitive for Detecting Surface C Difficile Contamination
Investigators found 16S rRNA gene qPCR to be more sensitive than culture for detecting C difficile on environmental surfaces.
Antimicrobial Stewardship Programs Reduce Infections, Mortality in Outpatient Dialysis Centers
Implementation of antimicrobial stewardship programs in outpatient dialysis centers reduce infections caused by multidrug-resistant organisms, including Clostridium difficile.
Sofosbuvir-Based DAA Regimens Effective for Achieving 12-Week SVR in Chronic HCV
The results of a recent study indicate that combination DAA regimens that include sofosbuvir are effective for achieving SVR in patients with chronic hepatitis C virus and compensated liver cirrhosis.
Nationwide HIV Viral Suppression Rates Tripled From 1997-2015
Investigators found associations between ART and ISTI-based regimens and increased viral suppression rates across the United States.
C Difficile Infections Significantly Impact Patients' Work, Health-Related Quality of Life
A new survey found that Clostridium difficile infections have a substantial impact on the health-related quality of work, work life, and physical activity of those who are infected.
Novel Antibacterial Demonstrates Superiority to Vancomycin for C Difficile Infection
Ridinilazole caused less microbiota disruption, and investigators believe it may be superior to vancomycin for preventing Clostridium difficile infection recurrence.
Ribavirin Use in Conjunction with DAA Therapy Predicts Mental Health Decline in Patients with HCV
The dual use of ribavirin and direct-acting antivirals during treatment for hepatitis C virus was found to independently predict decline in mental health-related quality-of-life.
FMT Consistently Demonstrates Efficacy for Recurrent C. difficile Infections
Clinical trials consistently demonstrate that fecal microbiota treatment is an effective treatment strategy for recurrent CDI, yet standardization practices vary.
Microbiota-Based Enema Prevents Recurrent C. difficile Infections
One phase 2 study showed that RBX2660, a microbiota-based drug comprised of human stool, was effective in 77.8% of patients.
Probiotic-Based Sanitation Reduces Hospital Infections Better Than Chlorine
A probiotic hygiene system resulted in a greater reduction of healthcare-associated infections and surface bacteria than chlorine-based cleansers, including a 66.6% reduction of C. difficile.
Fecal Transplantation a Feasible Antibiotic Alternative for C. Difficile Treatment
Fecal microbiota transplant and oral metronidazole are equally effective and tolerated for C. difficile treatment.
Greater HCV Treatment Needed in Care for People Who Inject Drugs
Researchers suggest a need exists for integration of hepatitis C treatment into all facets of addiction care for individuals who inject drugs.
Switching to Generic Levetiracetam Associated With Minimal Impact on Seizure Frequency
Converting from brand-name levetiracetam to generic version does not greatly increase seizure frequency among patients with epilepsy.
ADHD Risk Increases for Firstborn Children with Siblings
Firstborn children with ≥2 younger siblings have a 1.71 times higher risk of developing ADHD compared to children without siblings.
Higher Costs, In-Hospital Mortality in Clostridium difficile with Ulcerative Colitis/Crohn's Disease
Patients with a co-infection of Clostridium difficile and ulcerative colitis or Crohn’s disease have higher rates of in-hospital mortality and health care resource utilization.
Combination DAA Drug Regimen Safe, Effective for HCV-Related Cirrhosis
A new analysis shows a combination of ombitasvir/paritaprevir, ribavirin, and dasabuvir is safe and effective among older patients with HCV and cirrhosis.
Researcher Introduces New HCV Infection Mathematical Model
A University of Surrey research professor has developed a mathematical model based on earlier models, for monitoring HCV progression and treatment response.
SHP465 Amphetamine Salts Improved Problem Solving, Attention in Adults with ADHD
An amphetamine salts mixture (SHP465) showed efficacy in improving problem solving and sustaining attention in ADHD adults.
Screening for Clostridium difficile at Admission Reduces Outbreak Risk in the Surgical Unit
This is the first US initiative in to address the potential role of screening and isolation of asymptomatic C. difficile carriers in an outbreak setting as an adjunct to standard infection prevention measures.
PCR and EIA Tests Not Reliable for Distinguishing Clostridium difficile from Colonization
In patients with hematologic malignancy, the polymerase chain reaction or enzyme immunoassay testing modalities may not be accurate for C. difficile diagnosis.
Children with ADHD Likelier to Use Marijuana, Drugs Later in Life
Adolescents with ADHD were more likely to use marijuana and cigarettes at earlier ages, which increased their risk of continuing substance use into adulthood.
Prenatal Pollution Exposure, Poverty Increase ADHD Risk in Children
Prenatal exposure to polycyclic aromatic hydrocarbons, as well as lifelong poverty, increased ADHD symptoms in children.
Toxigenic Clostridium difficile Lower Than VRE in Long-Term Care
Patients receiving long-term care more likely to test positive for VRE than toxigenic C. difficile.
Transmission of HIV-1 Drug Resistance is On the Rise
Drug resistance is increasing among HIV-positive patients, driven partly by transmission of resistance to and by ARV-naïve patients.
Microbiome Composition Offers Insight into Clostridium difficile Risk Among Dementia Patients
Long-term care facility residents with advanced dementia have substantial dysbiosis of their gut microbiome which may be able to identify subjects at high risk of C. difficile colonization.
HIV Patients Older Than 50 Live with Multimorbidities, Higher Disease Burden Than HIV-Negative Persons
The study adds new data in the developing world for the aging HIV population, suggesting that long-term cART exposure and HIV duration have harmful effects.
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