Human Trials Could Begin for Macular Degeneration Stem Cell Therapy
FDA trial approval would make this trial the first ever to test a stem cell-based therapy derived from induced pluripotent stem cells for treating any disease.
Aflibercept Benefits Bevacizumab-Unresponsive Diabetic Retinopathy Patients
A new analysis of an ongoing clinical study offers insights for treating retinal vein occlusion in poor responders to bevacizumab.
Statins May Reduce Risk of Retinopathy in Diabetes Patients
Statins are already a common therapy among patients with type 2 diabetes. Its cholesterol-lowering benefits may help retain patient vision longer.
Early Gene Therapy Trials for Retina Disorder Yield Promise
University of Pennsylvania investigators conducted an interim analysis of a year-long study on intraocular injections of a mutation-specific gene therapy when one patient showed dramatic early improvements.
Investigators Seek Optimized Ophthalmology Clinical Trial Outcomes
A team of clinicians and investigators are working to define core outcome sets that it hopes will increase the utility of randomized clinical trials and stimulate research.
New Scale Measures Complication Risks for COPD Patients
About half of all patients with COPD suffer from serious adverse events following a hospital discharge, yet physicians cannot accurately distinguish which are at risk.
Cognitive Behavioral Therapy Improves COPD Patient Anxiety
Some of the most common symptoms of COPD drive anxiety in its patients. An England-based study sought out a cost-effective response.
Common Glaucoma Visual Test Lacks Consideration for Central Vision Loss
The 24-2 visual field test was comparably worse than other tests in consideration to glaucoma patients' central vision.
Novel Imaging Technique Provides Potential Improvement for AMD
A new imaging technique may provide improvements to the diagnosis and treatment of diseases like age-related macular degeneration (AMD).
Macular Degeneration Patient Visual Hallucinations Associated with Retina
The effects of Charles Bonnet Syndrome have been fairly documented, yet its pathology has been minimally assessed.
Atypical Protein Kinase C Targeted in Anti-VEGF Unresponsive Patients
Traditional therapy includes anti-VEGF injections into the eye. This is effective in many patients, but some remain unresponsive. Recent studies have suggested this new target.
Location Crucial to Corticosteroid Treatment for Uveitic Macular Edema
A new phase 3 study suggests that physicians should shift away from periocular injections, and towards intravitreal injections of corticosteroids for uveitic macular edema.
Mediterranean Diet Associated with 41% Risk Reduction for AMD
A comparison of patients in a pair of European-based studies tracking adherence to the diet found those eating healthier were significantly less likely to develop late-stage AMD.
Alzheimer and Dementia Projected to Especially Affect Black and Hispanic Americans
Investigators stressed the importance of culturally competent care for patients with dementia and support for their caregivers.
Neural Responses to Positive and Negative Events Moderate Depression Risk
The robustness of neural responses to positive and negative events may modify adolescent girls’ risk of depression, according to a new study.
Malaria Drug Amodiaquine Improves Blood Vessel Growth in AMD
In animal models, not only did the drug help protect apelin function-deficient models from laser-induced choroidal neovascularization, but it did it through unique mechanisms that were independent of VEGF function.
Smoking, Depression in Parents Linked with ADHD in Children
A paternal smoking amount of more than 15 cigarettes per day was significantly associated with children's ADHD.
New Tool May Help Identify Young Children At Risk of Developing Depression as Teens
The Childhood Behavior Checklist may help primary care physicians determine if young children are at risk for developing major depressive disorder or anxiety disorders in their teenage and young adult years.
New Indicators for Alzheimer Disease May Be Found in the Eye
The results of a new study point to age-related macular degeneration, diabetic retinopathy, and glaucoma as potential early warning signs that an individual is at risk for developing Alzheimer disease or dementia.
The Need for Paternal Postnatal Depression Screening
Researcher from the Indiana University School of Medicine found that at well-child visits 4.4% of fathers reported symptoms of depression compared to 5% of mothers.
Systematic Appraisal Shows AMD Meta-Analyses Lack Reliability
The first meta-analysis of AMD clinical meta-analyses shows many have methodological limitations—more so those sponsored by industry than those sponsored by governments.
ER Alcohol Intervention Reduces Teen Depression, Partner Violence
A single session with a therapist significantly reduced depression for up to 3 months and dating violence perpetration for up to 12 months. The computer-based intervention reduced both for 6 months.
In Vitro Model Provides Evidence for C3a Antagonists as AMD Therapy
To the knowledge of researchers, this is the first demonstration to show C3a can stimulate basal deposit production by normal human RPE cells.
ICO Publishes New Guidelines for Diabetic Retinopathy
Importantly, they are not directed toward ophthalmologists, but at general physicians and public healthcare professionals.
Depression Increases Risk of Cognitive Decline, Dementia
Researchers found that patients with depression were at increased risk of cognitive decline long before dementia could be diagnosed.
Patients with Concurrent Cataracts, Wet AMD Safe to Undergo Cataract Surgery
Most patients, whether or not they had preoperative fluid, saw improved BCVA post-surgery, and there were no significant differences in central subfield thickness.
Could ELOVL4 Expression be a Key to Preventing Diabetic Retinopathy?
Diabetes causes ELOVL4 to be downregulated, weakening the tight junctions. Researchers hope that replacing these lipids could be a treatment for diabetic retinopathy.
Novel Hydrogel Could Be Used for Glaucoma, Macular Degeneration
The researchers hope they will be able to use this template as a drug delivery solution for a variety of eye diseases.
Potential New Drug Target for Age-Related Macular Degeneration Identified
Those with the AMD showed greater expression of miRNA-150 than those without, offering evidence that miRNA-150 could be used as a potential biomarker—and drug target—for AMD.
Irregular Menstruation Common in Adolescent Type 2 Diabetes
The study showed that 21% of the girls with T2D also had menstrual dysfunction suggestive of polycystic ovarian syndrome.
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