FDA Approves Mouthpiece to Treat Obstructive Sleep Apnea as Class II Device
The daytime-nighttime appliance named DNA, serves as a novel alternative to existing treatment options for mild-to-moderate obstructive sleep apnea.
Modified Uvulopalatopharyngoplasty and Tonsillectomy are Options for Obstructive Sleep Apnea
Results indicated similar outcomes between those who underwent tonsillectomy and mUPPP, with minor differences favoring the tonsillectomy group.
Phase 3 Data Support Myelodysplastic Syndromes Treatment as Potential First-in-Class Therapy
Promising results from the IMerge phase 3 clinical trial met the primary and secondary endpoints in the investigation of imetelstat, a novel telomerase inhibitor developed for hematologic malignancies.
Neutrophil, Platelet Engraftment is Successful with Briquilimab in Patients with Sickle Cell Disease
The targeted patient population included those with sickle cell disease or beta thalassemia who were considered at high risk for complications, or otherwise ineligible for standard myeloablative hematopoietic stem cell transplant.
Vaso-Occulsive Crisis: The Future of Treating Patients with Sickle Cell Disease in Emergency Departments
"The challenge right now is that we have no therapies in the emergency department to treat acute pain, outside of pain medications and IV opioids," Dr. Claudia Morris says in an interview.
Treating Acute Myeloid Leukemia Starts With Good Quality Data
The motive of the study wasn't to implement hematopoietic stem cell transplantation (HSCT) programs worldwide, but as a contribution to comprehensive cancer control efforts.
Corinna Schultz, MD, Shares How Pediatricians Can Discuss Sickle Cell Trait With Patients, Families
According to Dr. Corinna Schultz, a key part of the conversation of sickle cell trait (SCT) is centered around reproductive choices for the patient in the future.
The Future of Treatment for Children with Acute Myeloid Leukemia and TP53 Gene Mutation
Dr. Adam Lamble recommends that pediatric patients with AML and TP53 status should now be considered for transplant in first remission, and novel interventions are warranted.
Amending the Global Gap in Acute Myeloid Leukemia Data
Dr. Molly Tokaz and Dr. Lisa Force discuss the extensive data they collected on the utilization of hematopoietic stem cell transplantation (HSCT) for patients with AML.
From Early Hypothesis to Clinical Data About Reducing Vaso-Occlusive Episodes with Arginine Therapy
Almost 25 years later, Dr. Claudia Morris concluded 2022 by presenting phase 2 data at the 64th ASH Annual Meeting that demonstrated the therapy's benefit, and her original premise. Her team's phase 3 trial evaluating Arg is currently underway.
Novel Data on Rare Gene Mutation in Children With AML Indicate Need for High-Risk Status
Dr. Adam Lamble shares that outcomes for pediatric patients with acute myeloid leukemia that have TP53 status are inferior to other patients with high-risk disease.
Sickle Cell Trait Complications are Overlooked in Healthcare
Dr. Corinna Schultz talks about her latest data and the growing body of literature showing medical complications that can come with sickle cell trait.
Haydar Frangoul, MD: The Sickle Cell Disease Population Needs More Options
"Using CRISPR/Cas9 you are able to actually fix a disease, that otherwise, was not fixable," Dr. Haydar Frangoul explains the data he presented at ASH 2022.
The Growing Advanced Practice Professional Workforce Counteracts Consistent Decline of Physicians
New data revealed the amount of collective physician work hours in the US has been consistently declining for 20 years.
Haydar Frangoul, MD: Exa-Cel Eliminates Vaso-Occlusive Crises, Increases HbF
New developments in gene therapy offer a promising perspective of a future where curing sickle cell disease (SCD) is possible.
The Importance of Oxygen Saturation, Desaturation When Assessing Obstructive Sleep Apnea
Previous studies aimed at understanding the association between intermittent hypoxia and impaired vigilance in patients with OSA provided conflicting results.
Sara Mednick, PhD, Shares a New Perspective of Sleep Health
Sleep expert Dr. Sara Mednick says one of the major goals to improve sleep health isn't simply for health benefits, but because it's essential to repair the daily buildup of toxins that accumulate during each wake period.
ASH 2022 Data Support Peer-Mediated Pain Management Groups for Patients with Sickle Cell Disease
Expert Stephanie Guarino, MD, MSHP, shares her plan for the future of pain management specifically for sickle cell disease is based on results from a series of studies.
PhenX Toolkit Updated to Include the Burden of Pain in Sickle Cell Disease
More research presented by Dr. Stephanie Guarino resulted in a recommended guideline designed for investigating sickle cell disease pain to standardize and enhance the quality of data.
Adam Lamble, MD: We Could Do Better Treating Pediatric Acute Myeloid Leukemia
Data from the largest investigation of TP53 mutations in pediatric patients with acute myeloid leukemia (AML) is presented at the ASH 2022 Annual Meeting.
Corinna Schultz, MD: Does Sickle Cell Trait get Addressed?
"There's no national guidance on how this information should be delivered back to families, which leaves it up to each state's newborn screening program to decide the best route that they see fit," Dr. Corinna Schultz explains.
Stephanie Guarino, MD, MSHP: How the Patient-Provider Relationship Impacts SCD-Related Pain
Dr. Stephanie Guarino's novel analysis found a significant relationship between self-efficacy in adults with SCD, and experiences of disease-related stigma.
Claudia Morris, MD, Uncovers Potential New Mechanism of Action for Hydroxyurea
In her mitochondrial work, Dr. Claudia Morris made a novel discovery that wasn't discussed in her presentation at the ASH 2022 Annual Meeting.
Experts at ASH 2022 Share Global Data on Acute Myeloid Leukemia
"Acute myeloid leukemia (AML) remains the most deadly disease among adults, with a five year overall survival of less than 30%," lead investigator Dr. Molly Tokaz says in an interview.
Fetal Hemoglobin Safely Increases with Escalated Hydroxyurea in Infants with Sickle Cell Anemia
Compared with infants kept on a standard dose of hydroxyurea, those receiving escalating doses showed greater increases in HbF and HB without significant toxicity.
New Data from Largest Lovo-cel Gene Therapy Trial in Sickle Cell Disease
Updated findings from the ongoing clinical trial investigating lovo-cel in sickle cell disease and persistent anemia allude to the possibility that a contributing factor of anemia was identified.
Arginine Therapy Shows Positive Impacts on Sickle Cell Disease in ASH 2022 Data
According to data presented at the ASH 2022 Annual Meeting, this is the first suggestion of a hydroxyurea-related impact on mito activity in patients with sickle cell disease.
Identifying Age-Related Macular Degeneration with AI Deep Learning Model
The results from the artificial intelligence deep learning model indicated alterations in the SD-OCT imaging regions attributed to the retinal nerve fiber and choroid layers.
Investigators Identify Comprehensive Research Priorities for Pediatric Dermatology
Pediatric care requires understanding, not only of the disease impact, but also its presentation and management in children.
Study Evaluates Link Between Chronic Stress and Insomnia in Aging Population
Findings revealed that self-health issues, family-health issues, and financial stress were the leading co-occurrences in older adults during the beginning of the pandemic.
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