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The IBIS-I randomized control trial included women of ages 35-70 from 37 health centers in eight countries from April, 1992, until March, 2001 that were deemed to be at increased risk of developing breast cancer (by virtue of family history of breast cancer or abnormal benign breast disease), and randomized to treatment with oral tamoxifen or placebo for 5 years.

This 25-year-old African-American man has had this papular rash for the last 2 years following a short haircut. Initially he had pustules, itching and inflammation but currently only has itching papules that are slowly enlarging. Triamcinolone 0.1% ointment has helped the itching. Past history and remainder of physical examination is noncontributory.

In March, the television news show 60 Minutes devoted a segment to a clinical trial using polio virus to treat glioblastoma multiforme. The segment called "Killing Cancer" did a good job of illustrating the potential power of this new treatment as well as the problems associated with glioblastoma multiforme which typically kills patients in a matter of months.

Sometimes even the most seasoned endocrinologists will encounter a patient who they have trouble finding a diagnosis. There is now an effort to use advances in science to help find answers for some of the field's most troubling questions