Hormonal Disorders

An analysis comparing those who switched against those who did not, results of the study suggest switching levothyroxine generics did not result in a negative impact on TSH levels in adult patients.

In this listicle, which was created for inclusion in the thyroid disorders edition of our Disease State Series, readers will find a curated list of top guidelines for the management of thyroid disorders composed by our editorial team with assistance from Dr. Elizabeth Pearce.

As part of our thyroid disorders installment of the Disease State Series, we have created a list of clinically relevant reviews related to the management of thyroid disorders. Our list includes reviews examining hypothyroidism, hyperthyroidism, thyroid eye disease, and thyroid management during pregnancy.

In this section of the thyroid disorders edition of our Disease State Series, readers will find an aggregate of resources for primary care providers. These resources were curated by our editorial staff with the help of key opinion leaders to not only provide insight and management of thyroid disorders for clinicians but also offer helpful resources to provide patients and caregivers.

An analysis of data from 1860 mother-child pairs suggests presence of abnormal maternal thyroid hormone levels could help in the prediction of behavioral and emotional health problems in male offspring at 4 years of age.

A cross-sectional study of more than 1000 patients suggests presence of MACS in patients with benign adrenal tumors was associated with increased prevalence and severity of hypertension as well as an increase in the likelihood of requiring insulin therapy in type 2 diabetes.

Announced on December 30, the approval of levoketoconazole (Recorlev), a cortisol synthesis inhibitor, is for the treatment of endogenous hypercortisolemia in adult patients with Cushing’s syndrome for whom surgery is not an option or has not been curative.

Each month, our editorial staff compiles a month in review highlighting the most popular content from the past month. December's month in review features new guidelines, stories on the effect of delayed visits, and more.

A retrospective analysis of data from more than 170 patients with Cushing syndrome and hyperglycemia provides insight into the effects of curative treatment on hyperglycemia among these patients.

A new analysis from UNSW Sydney details the prevalence of thyroid cancers in the next decade attributable to current levels of overweight and obesity among the population in Australia.

A systematic review and meta-analysis suggest presence of hypothyroidism or TAI could have a negative influence on AMH levels among women.

An analysis of more than 25k patients using levothyroxine demonstrates the impact of appointment delays on TSH levels among these patients.

The latest endocrine case report from Brady Pregerson, MD, features a woman in her mid-30s presenting with swollen glands lasting for the past 3 days and an associated sore throat. Can you determine the correct diagnosis?

An analysis of nearly 400 patients suggests undergoing thyroid radiofrequency ablation in ambulatory settings was associated with increased risk of intraoperative, postoperative, and perioperative side effects than those performed in operating room settings.

An analysis of more than 650 thyroid eye disease patients is providing clinicians with insight into the most common comorbidities and risk factors associated with increased disease severity in patients with TED.

An analysis of data from OPTIC and OPTIC-X provide insight into the effects of teprotumumab in longer duration thyroid eye disease and among patients who were nonresponders in the original trial.

Results of a bioavailability, crossover study suggest use of proton pump inhibitors did not interfere with the absorption of levothyroxine sodium oral solution.

Analysis of claims data from the Symphony database offers clinicians greater insight into the impact of diabetes, both type 1 and type 2, on thyroid eye disease in US patients.

A systematic review and meta-analysis presented at AACE 2021 details the risk of cardiovascular disease in patients with thyroid cancer who have undergone thyroidectomy.

Data from a phase 1 trial comparing dosing 15 and 30 minutes prior to breakfast suggests the wait time between intake of the novel liquid formulation of levothyroxine, Tirosint-SOL, and breakfast could be shortened to 15 minutes.

Data from LINC3 and LINC4 provide insight into the impact of dosing titration schedules on risk of hypocortisolism-related adverse events associated with osilodrostat use in patients with Cushing's disease.

A study from ENDO 2021 indicates moderate-to-severe COVID-19 infections are associated with atypical thyroid inflammation.

A randomized, 3-arm study is giving further insight into the effects of levothyroxine monotherapy compared against a thyroid combination therapy and desiccated thyroid extract for management of hypothyroidism, particularly in patients with Thr92AlaD2 polymorphism.

An analysis of more than half a million thyroid hormone users indicates more than 30% were also concurrently receiving a medication known to interfere with thyroid function tests.

An analysis of data from the TRUST trial supports guideline recommendations against levothyroxine for reducing depressive symptoms in older adults with subclinical hypothyroidism.