
Despite new therapies, IgAN still progresses to kidney failure in most patients. The panel reviews who is at greatest risk, which targets matter, and how hematuria fits alongside proteinuria and eGFR.
Nephrology experts discuss the persistent clinical burden of IgA nephropathy, the 2025 KDIGO framework, mechanisms and trial data for newly approved B-cell-targeted therapies, safety monitoring, and practical strategies for treatment selection, sequencing, and personalization.

Despite new therapies, IgAN still progresses to kidney failure in most patients. The panel reviews who is at greatest risk, which targets matter, and how hematuria fits alongside proteinuria and eGFR.