Peer Exchange

Hypercortisolism is increasingly recognized as an underdiagnosed contributor to resistant hypertension, cardiovascular disease, and broader cardiometabolic dysfunction. In this Peer Exchange, a panel of expert cardiologists discusses the evolving evidence linking cortisol excess to difficult-to-control hypertension, explores practical approaches to patient identification and screening, and reviews the implications of recent studies, including MOMENTUM and CATALYST. The faculty examine emerging treatment strategies, the role of multidisciplinary care, and opportunities to improve long-term outcomes through earlier recognition and targeted management of hypercortisolism. Throughout the discussion, they highlight how increasing awareness of cortisol excess may help clinicians uncover a potentially reversible driver of cardiovascular risk in everyday practice.

This peer exchange brings together expert endocrinologists to discuss the recognition, diagnosis, and management of hypercortisolism across its evolving disease spectrum. The panel explores the links between cortisol excess, cardiometabolic dysfunction, type 2 diabetes, and resistant hypertension, while reviewing practical approaches to screening and confirmatory testing. Faculty also examine current treatment strategies, emerging clinical evidence, and the importance of multidisciplinary care to improve patient outcomes.

In this HCPLive Peer Exchange, Dr. Natalie Cusano moderates a comprehensive discussion with Dr. Sara Lubitz, Dr. Dolores Shoback, Dr. Andrea Ferenczi, and Dr. Azarmindokht Khosravi on hypoparathyroidism, covering its multisystem burden, diagnostic challenges, treatment strategies, and evolving therapeutic landscape.

In this HCPLive Peer Exchange series, expert panelists discuss key updates and clinical insights related to ASCVD. The discussion focuses on updated cardiovascular risk assessment guidelines and LDL cholesterol goals, practical strategies for initiating and escalating lipid-lowering therapy, and the critical role of patient communication, shared decision making, and long-term adherence in closing the persistent gap between guideline-recommended targets and real-world clinical outcomes.

Expert endocrinologists examine growth hormone deficiency across pediatric and adult populations, covering etiology, diagnosis, treatment options including long-acting analogs, real-world registry data, transition-of-care challenges, and strategies for optimizing long-term patient outcomes across the continuum of care.

In this HCP Live Peer Exchange series, expert panelists discuss key updates and clinical insights related to Psoriasis. The discussion focuses on the evolving treatment approaches in psoriasis and how they aim to achieve sustained disease control beyond short-term skin clearance. The panelists evaluated long-term efficacy and safety data to better understand durability of response and the potential for sustained remission in psoriasis. They also explored how to incorporate evidence-based, remission-focused strategies into clinical management and patient communication in everyday practice.

This HCPLive Peer Exchange series provides a comprehensive evaluation of Wilson disease, from its underlying pathophysiology and clinical manifestations to the diagnostic criteria that impact long-term patient quality of life. The panelists analyze the safety and efficacy of current and emerging therapeutic paradigms while offering practical, data-driven strategies to overcome management challenges and improve medication adherence.

In this Peer Exchange, Dr. Vivek Kaul moderates a comprehensive discussion with Jennifer Geremia, PA-C, and Sarah Enslin, PA-C, covering EPI's symptom recognition, high-risk populations, diagnostic testing, PERT therapy, dose optimization, multidisciplinary care coordination, and key recommendations for closing persistent care gaps.

In this HCP Live Peer Exchange series, expert panelists discuss key updates and clinical insights related to Psoriasis. The discussion focuses on the pathophysiology of hypercortisolism, and how it contributes to hypertension and cardiovascular risk. The panelists will review the current and emerging treatment landscape and consider how evolving therapies may influence patient outcomes. Finally, the panelists will discuss practical approaches to cardiovascular management, including interdisciplinary collaboration and referral considerations in the care of patients with hypercortisolism

In this HCPLive Peer Exchange series, expert panelists discuss key updates and clinical insights related to obstructive hypertrophic cardiomyopathy. The discussion focuses on the pathophysiology, symptoms, and diagnostic approaches for obstructive hypertrophic cardiomyopathy (oHCM) to provide a foundation for patient management. It also examines treatment strategies, best practices for optimizing care, and how recent clinical trial data can be applied to improve outcomes in oHCM patients.

In this HCPLive Peer Exchange series, expert panelists discuss key updates and clinical insights related to plaque psoriasis. The discussion focuses on the clinical and practical challenges of managing moderate to severe plaque psoriasis, while evaluating the evolving treatment landscape with a particular emphasis on IL-23 inhibitors and the value of matching adjusted indirect comparisons in evidence-based decision making. The panelists also share best practices for integrating comparative evidence into real world practice to guide treatment selection, support patient centered discussions, and optimize long term outcomes.

In this HCPLive Peer Exchange series, expert panelists discuss the critical link between chronic kidney disease (CKD) and cardiovascular risk, emphasizing the necessity of early diagnostic testing. The multidisciplinary panel—comprising a cardiologist, a family physician, and a cardiovascular clinical pharmacist—explores how the integrated cardio-kidney-metabolic (CKM) framework can be used to improve patient outcomes

In thisHCPLive Peer Exchange series, expert panelists discuss key updates and clinical insights related to primary biliary cholangitis. The discussion focuses on new second-line treatment data and improving fatigue/pruritus symptoms.

In this HCPLive Peer Exchange series, expert panelists discuss key updates and clinical insights related to hypoparathyroidism. The discussion focuses on the etiology, diagnosis, long-term complications, and novel treatment approaches in the management of hypoparathyroidism.

This program brings together leading nephrologists to discuss the evolving landscape of IgA nephropathy, highlighting advances in understanding disease mechanisms and the emergence of targeted therapies. The panel reviews key clinical data, explores the role of novel treatment strategies such as B-cell modulation, and examines how these innovations may reshape modern patient management.

Experts discuss Giant Cell Arteritis presentation, epidemiology and pathophysiology, tackling diagnostic hurdles and long‑term management. Experts also reviews current and emerging therapies that can improve outcomes while lowering risks.

Panelists explore challenges in diagnosing and managing Sjogren’s Disease, evaluate emerging therapies, and share key considerations for integrating novel treatments into clinical practice.

Panel of experts will discuss the persistent cardiovascular risk among patients with a history of ASCVD events and the importance of LDL-lowering in secondary prevention. Experts also evaluate current and emerging PCSK9-targeting therapies and share practical strategies for integrating PCSK9 inhibition into post-event lipid management to achieve optimal LDL-C control and improve long-term outcomes.

This series brings together experts to discuss advances in the early recognition, diagnosis, and treatment of transthyretin amyloid cardiomyopathy (ATTR-CM). The panel highlights evolving evidence on TTR stabilizers and gene-silencing therapies, as well as emerging clinical data that are shaping future approaches to improving outcomes and quality of life for patients with ATTR-CM.

This series brings together expert clinicians to examine evolving strategies in psoriatic disease management. Through discussions on early systemic intervention, the role of IL-17 inhibitors, shared inflammatory pathways, and preventive treatment approaches, the program highlights a proactive, multidisciplinary model focused on achieving sustained remission, improving quality of life, and reducing the risk of psoriatic arthritis progression.

In this HCPLive Peer Exchange, Linda Stein Gold, MD, moderates a dynamic discussion with Jennifer Soung, MD, and David Cotter, MD, exploring how recent advances in psoriasis and psoriatic arthritis research are transforming patient management. The panel examines persistent treatment gaps, evolving patient preferences favoring oral options, and new guideline updates redefining “topical failure.” They highlight pivotal data from EADV 2025, including the ICONIC-ADVANCE and ICONIC-LEAD trials of icotrokinra (ICO)—a first-in-class oral IL-23 receptor antagonist—and the APEX study of guselkumab in psoriatic arthritis, which demonstrated significant inhibition of radiographic progression. The discussion emphasizes patient-centered, mechanism-driven approaches to psoriasis and PsA care, underscoring how emerging oral and biologic therapies are reshaping treatment paradigms

Panelists discuss how optimizing topical therapeutic strategies across all severities of pediatric atopic dermatitis can improve symptom control, family quality of life, and long-term skin health through individualized, evidence-based, and family-centered care.

Four panelist discusses how advancing diagnostic precision, integrating novel MRAs like finerenone, and addressing real-world barriers in access and adherence are transforming HFpEF care and improving patient outcomes.

Panelists discuss how IL-17 inhibitors have emerged as first-line treatment options for moderate to severe hidradenitis suppurativa, with long-term data demonstrating sustained efficacy over 2 years, manageable cutaneous adverse effects, and the potential for combination with surgery and other systemic therapies to optimize patient outcomes.

Experts discuss the clinical implications of early and irreversible structural damage in psoriatic arthritis, comparing mechanisms of action and radiographic outcomes of IL-23 and IL-17 inhibitors, interpreting emerging trial data, and exploring how safety, onset speed, and domain coverage shape treatment decisions and therapeutic strategies.

Evan Dellon, MD, MPH; Glenn Furuta, MD; Bryan Sauer, MD, MSc, and Joy Chang, MD, MS, discuss how eosinophilic esophagitis (EoE) presents with dysphagia and adaptive eating behaviors in adults and children and requires endoscopic diagnosis with biopsies showing 15 or more eosinophils per high-power field. It can be effectively managed through shared decision-making between first-line therapies including proton pump inhibitors; topical swallowed steroids such as budesonide oral suspension; and elimination diets, with step-up options such as dupilumab for refractory cases and esophageal dilation for fibrostenotic complications.

Jared Butler, MD, MPH, MBA; Vivian Fonseca, MD; Lance Sloan, MD; and Michael J. Bloch, MD, discuss how to effectively manage resistant hypertension through a comprehensive approach that includes differentiating true resistance from pseudoresistance; implementing lifestyle modifications and optimal medical therapy with ACE inhibitors/ARBs, calcium channel blockers, and diuretics; and incorporating emerging treatments like endothelin receptor antagonists such as aprocitentan, which demonstrated significant blood pressure reduction in the PRECISION trial across diverse patient populations, including those with chronic kidney disease.

Panelists discuss the significance of elevated eosinophils as a biomarker in COPD—highlighting challenges in its measurement and its role in guiding personalized treatment—while navigating current management strategies for eosinophilic COPD, exploring the overlap with asthma through type 2 inflammation and its therapeutic implications, and emphasizing the critical importance of timely care escalation to prevent symptom worsening and improve long-term outcomes.

Richard Pratley, MD; Vivian Fonseca, MD, FRCP; Ralph DeFronzo, MD; Richard Auchus, MD, PhD; and Natalie Bellini, DNP, FNP, BC-ADM, CDCES, discuss how the groundbreaking CATALYST trial results revealed that approximately 25% of patients with difficult-to-control diabetes despite optimal medical management have hypercortisolism, representing a treatable cause of treatment-resistant diabetes that can be identified through simple dexamethasone suppression testing and managed with targeted therapies such as mifepristone or surgical intervention for adrenal adenomas.

Sayna Norouzi, MD; Jonathan Barratt, MBChB, PhD, FRCP; Andrew S. Bomback, MD, MPH; Bradley Dixon, MD; and Brendon Neuen, MD, discuss how the diagnostic challenges of C3 glomerulopathy (C3G) are addressed, current treatment strategies are explored, and emerging therapies, including insights from the VALIANT trial, may impact clinical practice.