
Dermatology experts share how IL‑23 therapies and comparative data boost clearance, cut switching, and improve psoriasis quality of life
In this HCPLive Peer Exchange series, expert panelists discuss key updates and clinical insights related to plaque psoriasis. The discussion focuses on the clinical and practical challenges of managing moderate to severe plaque psoriasis, while evaluating the evolving treatment landscape with a particular emphasis on IL-23 inhibitors and the value of matching adjusted indirect comparisons in evidence-based decision making. The panelists also share best practices for integrating comparative evidence into real world practice to guide treatment selection, support patient centered discussions, and optimize long term outcomes.

Dermatology experts share how IL‑23 therapies and comparative data boost clearance, cut switching, and improve psoriasis quality of life

Psoriasis severity goes beyond BSA: IGA, DLQI and high-impact areas redefine “moderate,” guiding when to move from topicals to systemic therapy.

Experts explain treat-to-target psoriasis care, aiming for near-clear skin, when to switch or add therapy, and why remission may reduce risks.

Experts reveal plaque psoriasis gaps: stubborn scalp, nails and joints, payer hurdles, and why early systemic therapy aims for lasting remission.



This episode, titled "Analyzing IL-23 Inhibitors in Psoriasis," features panelists discussing the future of IL-23 targeted therapies and the practical considerations surrounding the anticipated shift toward oral treatment options in plaque psoriasis.

In this episode, "Value of Utilizing Matching-Adjusted Indirect Comparisons (MAICs) in Psoriasis," the expert dermatologists explore the methodology behind matching adjusted indirect comparisons and their practical value in guiding evidence based treatment decisions for plaque psoriasis.

In "Evaluating Psoriasis Therapies using MAICs," our panel delves into several recent and clinically meaningful MAIC analyses comparing biologic therapies for plaque psoriasis, examining what the data reveals about relative efficacy across treatment classes and how these analyses have been validated over time.

This episode, titled "Continuing the Conversation on Treatments in Psoriasis," features panelists discussing the value and limitations of network meta-analyses as a tool for comparing multiple psoriasis therapies across different clinical trials simultaneously.

In this episode, "Evaluating IL-23 Inhibitors with Long-Term Data and Real-World Evidence," the expert dermatologists explore the distinct but complementary roles of long term extension studies and real world evidence in evaluating the durability and safety of biologic therapies for plaque psoriasis.

In the final episode, "Integrating Comparative Evidence to Optimize Psoriasis Treatment Decisions," the panelists explore how the full body of available evidence, including comparative analyses, long term extension studies, real world data, and clinical experience, can be integrated into practical treatment decision making for plaque psoriasis.