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This Year In Medicine 2025

Opinion|Videos|February 14, 2025

Ensifentrine (ENHANCE Trials) in COPD

Author(s)M. Bradley Drummond, MD, MHS, MeiLan K. Han, MD, MS, Emily Wan, MD MPH

Panelists discuss how the ENHANCE trials assessed ensifentrine in patients with chronic obstructive pulmonary disease (COPD) with moderate-to-severe airflow obstruction and a history of exacerbations. Outcomes showed improved lung function and reduced exacerbations. Clinically, ensifentrine may be used as monotherapy or an add-on, addressing diverse patient needs.

Episodes in this series

EP. 1 Overview and Diagnosis of COPD

EP. 1 Overview and Diagnosis of COPD

EP. 2 Risk Factors for COPD

EP. 2 Risk Factors for COPD

EP. 3 Mortality and Comorbidities with COPD

EP. 3 Mortality and Comorbidities with COPD

EP. 4 Health and Economic Burden of COPD

EP. 4 Health and Economic Burden of COPD

EP. 5 Treatment of COPD Based on Symptoms

EP. 5 Treatment of COPD Based on Symptoms

EP. 6 GOLD 2025 Report: Prebronchodilator Spirometry and Diagnosis of COPD

EP. 6 GOLD 2025 Report: Prebronchodilator Spirometry and Diagnosis of COPD

EP. 7 GOLD 2025 Report: Lung Microbiome and Chest CT Imaging in COPD

EP. 7 GOLD 2025 Report: Lung Microbiome and Chest CT Imaging in COPD

EP. 8 GOLD 2025 Report: Addressing Heart Disease in COPD

EP. 8 GOLD 2025 Report: Addressing Heart Disease in COPD

EP. 9 Blood Eosinophil Counts in COPD

EP. 9 Blood Eosinophil Counts in COPD

EP. 10 GOLD 2025 Report: Ensifentrine, a New Treatment in COPD

EP. 10 GOLD 2025 Report: Ensifentrine, a New Treatment in COPD

EP. 11 GOLD 2025 Report: Dupilumab, a New Treatment in COPD

EP. 11 GOLD 2025 Report: Dupilumab, a New Treatment in COPD

EP. 12 Ensifentrine (ENHANCE Trials) in COPD

EP. 12 Ensifentrine (ENHANCE Trials) in COPD

EP. 13 Maintenance Therapy and Adherence to COPD Treatment

EP. 13 Maintenance Therapy and Adherence to COPD Treatment

EP. 14 Vaccination and Pulmonary Rehabilitation in COPD

EP. 14 Vaccination and Pulmonary Rehabilitation in COPD

EP. 15 Future Outlook in COPD

EP. 15 Future Outlook in COPD

Video content above is prompted by the following:

Ensifentrine is recommended in the 2025 GOLD Report as a bronchodilator to improve dyspnea. Ensifentrine is also suggested as a potential anti-inflammatory therapy in stable COPD.
- What were the main patient eligibility criteria and clinical outcomes in the ENHANCE trials?
- How do you anticipate that ensifentrine will be used in clinical practice (ie, monotherapy, add-on, both)?

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