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Spotlight -

This Year In Medicine 2025

Opinion|Videos|February 14, 2025

Ensifentrine (ENHANCE Trials) in COPD

Author(s)M. Bradley Drummond, MD, MHS, MeiLan K. Han, MD, MS, Emily Wan, MD MPH

Panelists discuss how the ENHANCE trials assessed ensifentrine in patients with chronic obstructive pulmonary disease (COPD) with moderate-to-severe airflow obstruction and a history of exacerbations. Outcomes showed improved lung function and reduced exacerbations. Clinically, ensifentrine may be used as monotherapy or an add-on, addressing diverse patient needs.

Episodes in this series

EP. 1 Overview and Diagnosis of COPD

EP. 1 Overview and Diagnosis of COPD

EP. 2 Risk Factors for COPD

EP. 2 Risk Factors for COPD

EP. 3 Mortality and Comorbidities with COPD

EP. 3 Mortality and Comorbidities with COPD

EP. 4 Health and Economic Burden of COPD

EP. 4 Health and Economic Burden of COPD

EP. 5 Treatment of COPD Based on Symptoms

EP. 5 Treatment of COPD Based on Symptoms

EP. 6 GOLD 2025 Report: Prebronchodilator Spirometry and Diagnosis of COPD

EP. 6 GOLD 2025 Report: Prebronchodilator Spirometry and Diagnosis of COPD

EP. 7 GOLD 2025 Report: Lung Microbiome and Chest CT Imaging in COPD

EP. 7 GOLD 2025 Report: Lung Microbiome and Chest CT Imaging in COPD

EP. 8 GOLD 2025 Report: Addressing Heart Disease in COPD

EP. 8 GOLD 2025 Report: Addressing Heart Disease in COPD

EP. 9 Blood Eosinophil Counts in COPD

EP. 9 Blood Eosinophil Counts in COPD

EP. 10 GOLD 2025 Report: Ensifentrine, a New Treatment in COPD

EP. 10 GOLD 2025 Report: Ensifentrine, a New Treatment in COPD

EP. 11 GOLD 2025 Report: Dupilumab, a New Treatment in COPD

EP. 11 GOLD 2025 Report: Dupilumab, a New Treatment in COPD

EP. 12 Ensifentrine (ENHANCE Trials) in COPD

EP. 12 Ensifentrine (ENHANCE Trials) in COPD

EP. 13 Maintenance Therapy and Adherence to COPD Treatment

EP. 13 Maintenance Therapy and Adherence to COPD Treatment

EP. 14 Vaccination and Pulmonary Rehabilitation in COPD

EP. 14 Vaccination and Pulmonary Rehabilitation in COPD

EP. 15 Future Outlook in COPD

EP. 15 Future Outlook in COPD

Video content above is prompted by the following:

Ensifentrine is recommended in the 2025 GOLD Report as a bronchodilator to improve dyspnea. Ensifentrine is also suggested as a potential anti-inflammatory therapy in stable COPD.
- What were the main patient eligibility criteria and clinical outcomes in the ENHANCE trials?
- How do you anticipate that ensifentrine will be used in clinical practice (ie, monotherapy, add-on, both)?

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Patricia Junquera, MD; Maria Collado, MD; Erin C. Crown, MHSPAS, PA-C, Psych-CAQ

Community Collab: The Evolving Role of FcRN Inhibitors in the Management of Generalized Myasthenia Gravis (gMG)

Community Collab: The Evolving Role of FcRN Inhibitors in the Management of Generalized Myasthenia Gravis (gMG)

James F. Howard Jr, MD, FAAN; Tuan Vu, MD

The Presbyopia-Correcting and Toric IOL Playbook: Game-Changing Surgical Strategies to Enhance Patient Outcomes

The Presbyopia-Correcting and Toric IOL Playbook: Game-Changing Surgical Strategies to Enhance Patient Outcomes

Uday Devgan, MD, FACS, FRCS

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Juan D. Oms, MD, FAPA; Linda Collado, MD, DABPN, FAPA; Ginger Shupe, MD

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

Stephen J Greene, MD; Anuradha Lala-Trindade, MD

Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Pam R. Taub, MD, FACC, FASPC; Payal Kohli, MD, FACC

When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

Mile Brujic, OD, FAAO; Pierce Kenworthy, OD, FAAO; Blair Lonsberry, MS, OD, MEd, FAAO

Burst CME™: Burden of Sickle Cell Disease

Burst CME™: Burden of Sickle Cell Disease

Matthew Heeney, MD; Biree Andemariam, MD

Burst CME™: Burden of Sickle Cell Disease

Burst CME™: Burden of Sickle Cell Disease

Matthew Heeney, MD; Biree Andemariam, MD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Michelle Petri, MD, MPH; Shivani Garg, MD, PhD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Michelle Petri, MD, MPH; Shivani Garg, MD, PhD

Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Carl J. Danzig, MD, FASRS

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

Rahul Gosain, MD, MBA; Rohit Gosain, MD

From Suspicion to Stabilization: Early Recognition and Treatment of Paraneoplastic LEMS

From Suspicion to Stabilization: Early Recognition and Treatment of Paraneoplastic LEMS

Charu Aggarwal, MD, MPH, FASCO; Erminia Massarelli, MD, PhD, MS; Ruham Nasany, MD

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Interstitial Lung Abnormalities: Recognition, Risk Stratification, and When to Act

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Evaluating Clinical and Real-World Evidence in Hypercortisolism