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This Year In Medicine 2025

Opinion|Videos|September 23, 2024

Familial Chylomicronemia Syndrome: Diagnosis, Genetic Factors, and Long-Term Health Implications

Author(s)Kausik K. Ray, MD, MRCP: From the Department of Public Health, Gerald Watts, MD, PhD

Panelists discuss how familial chylomicronemia syndrome (FCS) is characterized by severe hypertriglyceridemia and genetic mutations in the LPL gene, highlighting the key diagnostic criteria and complications, such as acute pancreatitis, while emphasizing the impact of untreated FCS on patient quality of life and long-term health risks.

Episodes in this series

EP. 1 Familial Chylomicronemia Syndrome: Diagnosis, Genetic Factors, and Long-Term Health Implications

EP. 1 Familial Chylomicronemia Syndrome: Diagnosis, Genetic Factors, and Long-Term Health Implications

EP. 2 Quality of Life and Diagnostic Considerations for FCS

EP. 2 Quality of Life and Diagnostic Considerations for FCS

EP. 3 PALISADE Study: Plozasiran’s Efficacy and Potential in Reducing Triglycerides and Pancreatitis

EP. 3 PALISADE Study: Plozasiran’s Efficacy and Potential in Reducing Triglycerides and Pancreatitis

EP. 4 Emerging Research of RNAi-Based Therapies for FCS

EP. 4 Emerging Research of RNAi-Based Therapies for FCS

EP. 5 Reflections on Plozasiran Trial Data and Future Potential

EP. 5 Reflections on Plozasiran Trial Data and Future Potential

EP. 6 SHASTA-2 Trial: Plozasiran’s Efficacy in Reducing Triglycerides and APOC3

EP. 6 SHASTA-2 Trial: Plozasiran’s Efficacy in Reducing Triglycerides and APOC3

EP. 7 Novel Research Frontiers on the Management of FCS

EP. 7 Novel Research Frontiers on the Management of FCS

Video content above is prompted by the following:

What is familial chylomicronemia syndrome (FCS), and how can it be distinguished from other forms of hyperlipidemia? What are the key clinical features and diagnostic criteria for FCS?
What are the potential complications and long-term health risks associated with untreated FCS?

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