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This Year In Medicine 2025

Opinion|Videos|December 2, 2024

Genital Mycotic Infection Treatment and Adverse Effects

Author(s)Rajiv Agarwal, MD, MS, Mark A. Meeker, DO, FACP, CPE , Martha Gulati, MD

Key Takeaways

Genital mycotic infections on SGLT-2 inhibitors are typically managed with topical antifungals, continuing the inhibitor unless infections are severe or recurrent.
Addressing adverse effects of GLP-1 receptor agonists involves discussing therapy benefits, considering dose adjustments, or exploring alternative treatments to maintain efficacy.
Patient concerns should be acknowledged, and a collaborative approach should be taken to balance treatment benefits with quality of life.

SHOW MORE

Panelists discuss the treatment of a patient with type 2 diabetes who develops a genital mycotic infection while on an SGLT-2 inhibitor, weighing the options of treating with topical antifungals versus discontinuing the medication, as well as addressing concerns for a patient on a GLP-1 receptor agonist and RAAS inhibitor who is experiencing adverse effects such as bloating and nausea while considering the benefits of continuing therapy.

In a patient with type 2 diabetes who develops a genital mycotic infection while on an SGLT-2 inhibitor, do you treat the infection with topical antifungals and continue the SGLT-2 inhibitor, or should the SGLT-2 inhibitor be discontinued?
A patient on a GLP-1 receptor agonist and RAAS inhibitor is experiencing bloating, nausea, and weight loss and expresses a desire to stop treatment. How should you address their concerns and manage these adverse effects while considering the benefits of continued therapy?

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