Integrating Hypercortisolism Screening into Clinical Practice

In the final episode, ‘Integrating Hypercortisolism Screening into Clinical Practice,’ the panelists explore practical strategies for improving recognition, screening, and management of hypercortisolism in routine clinical care. Drawing on emerging evidence and extensive clinical experience, the expert faculty discuss how clinicians can identify patients who may benefit most from screening, particularly those with difficult-to-control type 2 diabetes, resistant hypertension, and other cardiometabolic comorbidities that may signal underlying cortisol excess.

The panel of experts emphasizes the importance of targeted rather than universal screening, highlighting the need to focus on high-yield patient populations where the likelihood of detecting hypercortisolism is greatest. They discuss how clinical suspicion should be guided by both comorbidity burden and characteristic clinical features, while acknowledging the complexities involved in interpreting screening results and managing borderline or discrepant findings. The discussion also addresses practical considerations surrounding test selection, repeat testing, and the role of standardized screening pathways that may help streamline identification of at-risk patients across healthcare settings.

Throughout the conversation, the panelists stress the importance of multidisciplinary collaboration among endocrinologists, primary care physicians, cardiologists, and other specialists to reduce diagnostic delays and improve patient outcomes. They examine the challenges associated with expanding awareness of hypercortisolism and educating clinicians on appropriate testing, interpretation, and treatment strategies.

As the series concludes, the expert faculty reflect on the evolving understanding of hypercortisolism as a spectrum of disease and underscore the value of teamwork, patient engagement, and ongoing education. They also reinforce the importance of establishing the underlying etiology of hypercortisolism and pursuing curative treatment whenever possible, with surgery remaining the preferred first-line approach when appropriate. Thank you for watching this peer exchange series on hypercortisolism. Please subscribe to our newsletter for information on upcoming video series.