Feature|Videos|August 8, 2025

One Year Later: How Intranasal Epinephrine Is Changing Emergency Allergy Treatment

Fact checked by: Victoria Johnson

One year after neffy's approval, 4 clinicians and 1 PharmD examine its continuing impact on the field.

On August 9, 2024, the FDA approved the first needle-free epinephrine nasal spray under the name neffy (ARS Pharmaceuticals) for the emergency treatment of anaphylaxis in adults and children—a significant milestone in allergy care.1 One year later, this intranasal option has expanded the treatment landscape for severe allergic reactions, offering a discreet and easy-to-use alternative to autoinjectors. For many patients, especially children or those with needle aversion, this innovation represents not just convenience, but potentially life-saving accessibility.