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This Year In Medicine 2025

Opinion|Videos|April 7, 2025

Overview of the Biologics Approved in Atopic Dermatitis

Author(s)Melodie Young, MSN, A/GNP-C, FSDNP, DCNP , TJ Chao, MPAS, PA-C, Leigh Ann Pansch, MSN, FNP-BC, DCNP

Panelists discuss how the current biologic landscape for atopic dermatitis includes 4 distinct agents with complementary mechanisms: dupilumab targeting IL-4 and IL-13 pathways to broadly inhibit type 2 inflammation, lebrikizumab and tralokinumab both selectively blocking IL-13 to potentially offer similar efficacy with refined targeting, and nemolizumab uniquely addressing the IL-31 “itch cytokine” pathway—each representing different strategic approaches to modulating the complex immunopathology of the disease with specific advantages for different patient phenotypes.

Episodes in this series

4 experts are featured in this series.

EP. 1 Assessing Atopic Dermatitis Severity in Clinical Practice

4 experts are featured in this series.

EP. 2 Establishing Atopic Dermatitis Treatment Goals and Expectations With Patients

4 experts are featured in this series.

EP. 3 Moving Beyond Topical Treatments in Atopic Dermatitis Management

4 experts are featured in this series.

EP. 4 The Evolving Landscape for Atopic Dermatitis Treatment

4 experts are featured in this series.

EP. 5 Overview of the Biologics Approved in Atopic Dermatitis

4 experts are featured in this series.

EP. 6 Evaluating Biologic Treatment as Monotherapy for Atopic Dermatitis

4 experts are featured in this series.

EP. 7 Managing the Topical to Biologic Transition in Clinical Practice

4 experts are featured in this series.

EP. 8 Safety of Biologics in Atopic Dermatitis Treatment

4 experts are featured in this series.

EP. 9 Patient Considerations to Guide Biologic Treatment Selection in Atopic Dermatitis

4 experts are featured in this series.

EP. 10 Addressing Biologic Dosing and Adherence With Patients

4 experts are featured in this series.

EP. 11 Practical Considerations for Managing Atopic Dermatitis With Biologics

Video content above is prompted by the following:

We’ll go into more detail in a bit, but can you provide a brief introduction of the biologics currently approved for atopic dermatitis, including how they differ in their mechanisms of action?
Dupilumab (IL-4/IL-13 inhibitor)
Lebrikizumab (IL-13 inhibitor)
Tralokinumab (IL-13 inhibitor)
Nemolizumab (IL-31 inhibitor)

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