Recent Advances and Emerging Therapies in the Management of Alzheimer Disease
In this episode of MEDcast, expert geriatric psychiatrist and neurologist delve into the recent advances in the treatment of Alzheimer’s disease. We will discuss treatments that are on the cusp of FDA approval and others that are coming down the pipeline.
0:00 Introduction
1:25 An overview of the current standard of care in of Alzheimer’s disease
4:55 Pathophysiology of Alzheimer’s disease
6:58 Aducanumab and lecanemab for Alzheimer’s disease
9:45 Mechanism of action of anti-amyloid agents
11:19 Leaky cell theory in Alzheimer's disease
12:35 Efficacy and safety of aducanumab and lecanemab
13:26 Safety of emerging agents in Alzheimer’s disease
16:37 Practical implementation of lecanemab
19:23 Challenges in CMS coverage for treatments of Alzheimer’s
24:05 Efficacy and safety of Donanemab
25:35 Overcoming clinical inertia around emerging agents in Alzheimer’s disease
29:30 A look into the future of management of Alzheimer’s disease
31:30 Summary
