The study’s investigators suggest the results in this patient population may indicate rises in clinically diagnosed viral infections from viruses other than SARS-CoV-2 following pandemic lockdown changes.
The total number of admissions to a pediatric intensive care unit (PICU) for those with severe asthma exacerbations (SAE) in the Netherlands decreased in the first year of the COVID-19 pandemic, according to new findings, though they increased significantly for SAE in 2021 and 2022 as COVID-19 restrictions lifted.1
The investigators that reported these findings noted that this may have been a result of increases in clinically-diagnosed viral infections that were not SARS-CoV-2. The findings were part of a single-center study looking at trends of SAE cases involving PICU admissions prior to, during, and following COVID-19 restrictions in Amsterdam, as well as any links to environmental triggers or restriction alterations.
This research was led by Anke H. Maitland van der Zee PharmD, PhD, from the Department of Pulmonary Medicine at Amsterdam University Medical Center (UMC) in the Netherlands.
“While the incidence of asthma exacerbations in children during the COVID-19 pandemic has been evaluated, the incidence of SAE, specifically those requiring PICU admission and treatment, during the pandemic is, to our knowledge, not known,” Maitland and colleagues wrote, which led to the team assessing admissions to the PICU and related trends.2
The investigators used a retrospective cohort study design, carrying out their research at the Amsterdam UMC. This facility is a tertiary medical center that maintains a PICU with 12 beds that functions in the northwestern part of the Netherlands.
The research team looked at the electronic hospital records of children that were in the PICU between 2018 and 2022, with a unique focus on individuals with diagnosed SAE. Diagnoses were defined as cases in which exacerbations had been unresponsive to systemic corticosteroids, bronchodilators, and intravenous magnesium sulfate.
The team excluded subjects that were under 2 years old with wheezing, which they attributed to the fact that the differentiation between bronchiolitis and asthma for these patients was challenging. Only those aged 2 years and above were assessed.
The investigators looked into the subjects’ social, demographic, and clinical information, as well as the total number of PICU admissions reported at Amsterdam UMC. The team looked at data regarding closures of educational facilities, lockdown requirements,workplace restrictions, and other information which they found in the Oxford COVID Response Tracker.
The research team looked at links between SAE admissions each month and corresponding restrictions. They calculated the stringency score through the monthly scores of school closures and workplace closures.
Environmental elements such as ambient air pollution, secondhand smoke exposure, and exposure to pollen from 2018 to 2022 were considered by the investigators. Exposure measurements per day were put into monthly and yearly averages for the team’s comparisons.
Overall, the research team found that from January 2018 - December 2022, the PICU at Amsterdam UMC reported 228 total admissions of young patients with diagnoses of SAE. They concluded that the times in which stricter restrictions were in place, the data showed a reduction in admissions.
That said, after the relaxation of Amsterdam’s COVID-19 restrictions in the year 2021, the team noted that there was a notable surge in admissions to PICU for those with SAE. In fact, the investigators reported the highest incidence happened from August - November 2021, surpassing prior peaks in this time frame.
Furthermore, the research team could not identify a discernible link with air pollution or pollen levels among those they assessed.
“Therefore, in future pandemic preparedness planning, it is important to consider changes in other infectious diseases in a postrestriction period,” they wrote. “However, as this is a single-site study, these findings need to be studied further and replicated in a wider setting to better understand these observations.”