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Spotlight -

This Year In Medicine 2025

Opinion|Videos|November 24, 2025

The Underlying Causes of GCA: Environmental and Genetic Factors

Author(s)Robert Spiera, MD, John Stone, MD, MPH, Anisha Dua, MD, MPH

Episodes in this series

EP. 1 An Overview of Giant Cell Arteritis (GCA): Common Signs and Symptoms

EP. 1 An Overview of Giant Cell Arteritis (GCA): Common Signs and Symptoms

EP. 2 The Underlying Causes of GCA: Environmental and Genetic Factors

EP. 2 The Underlying Causes of GCA: Environmental and Genetic Factors

EP. 3 Current Gaps in Diagnostic Criteria Standards: Key Factors That Inform Diagnostic Decisions

EP. 3 Current Gaps in Diagnostic Criteria Standards: Key Factors That Inform Diagnostic Decisions

EP. 4 Non-Cranial Symptoms in GCA

EP. 4 Non-Cranial Symptoms in GCA

EP. 5 Imaging Modalities for Diagnosing GCA: What Clinicians are Doing in Clinic

EP. 5 Imaging Modalities for Diagnosing GCA: What Clinicians are Doing in Clinic

EP. 6 Discussing the Overlap of Polymyalgia Rheumatica in Patients With GCA

EP. 6 Discussing the Overlap of Polymyalgia Rheumatica in Patients With GCA

EP. 7 Diagnostic Blood Testing in GCA

EP. 7 Diagnostic Blood Testing in GCA

EP. 8 Expert Perspectives on the Reasons for Diagnostic Delay in GCA

EP. 8 Expert Perspectives on the Reasons for Diagnostic Delay in GCA

EP. 9 The Physical and Mental Quality of Life Impacts of GCA

EP. 9 The Physical and Mental Quality of Life Impacts of GCA

EP. 10 Current Standards of Care in GCA Treatment

EP. 10 Current Standards of Care in GCA Treatment

EP. 11 Real-World Complications Using Steroids to Treat GCA

EP. 11 Real-World Complications Using Steroids to Treat GCA

EP. 12 Current Pathway Treatment Targets in GCA

EP. 12 Current Pathway Treatment Targets in GCA

EP. 13 Reflecting on the Trial Landscape in GCA and History of Approved Agents

EP. 13 Reflecting on the Trial Landscape in GCA and History of Approved Agents

EP. 14 Clinical Experience with Tocilizumab and Upadacitinib in GCA Treatment

EP. 14 Clinical Experience with Tocilizumab and Upadacitinib in GCA Treatment

EP. 15 The Trial Design and Interim Results From the GCAptAIN Trial

EP. 15 The Trial Design and Interim Results From the GCAptAIN Trial

EP. 16 Experts Discuss the REPLENISH Trial for Polymyalgia Rheumatica

EP. 16 Experts Discuss the REPLENISH Trial for Polymyalgia Rheumatica

EP. 17 Reflecting on Trial Limitations in GCA: Painting a Future for IL-17A Targeting Therapies

EP. 17 Reflecting on Trial Limitations in GCA: Painting a Future for IL-17A Targeting Therapies

EP. 18 Hope on the Horizon: The Future of GCA Treatment

EP. 18 Hope on the Horizon: The Future of GCA Treatment

This video covers the following questions:

What do we currently understand about the underlying causes (i.e., pathogenesis and the inflammatory pathways) of GCA?
What role do genetics or environmental exposures appear to play in developing this disease?
How might the presence of comorbidities (such as hypertension, osteoporosis, cataracts, etc.) impact the screening and diagnosis of GCA? What diagnostic pearls can you share on screening patients for GCA with comorbidities?

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Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Expert Illustrations & Commentary: Visualizing Novel Therapeutic Targets for Patients with Major Depressive Disorder

Juan D. Oms, MD, FAPA; Linda Collado, MD, DABPN, FAPA; Ginger Shupe, MD

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

Cases and Conversations™: Navigating CKD and Heart Failure in T1D and T2D—Applying the Latest Guidelines and Evidence

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Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Advances in™: Lipoprotein(a) as a Target for ASCVD Risk Reduction – Updates for Clinical Practice

Pam R. Taub, MD, FACC, FASPC; Payal Kohli, MD, FACC

When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

When Mites Meet Their Match: Empowering Patients With Targeted Treatment for 𝘋𝘦𝘮𝘰𝘥𝘦𝘹 Blepharitis

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Burst CME™: Burden of Sickle Cell Disease

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Matthew Heeney, MD; Biree Andemariam, MD

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Burst CME™: Burden of Sickle Cell Disease

Matthew Heeney, MD; Biree Andemariam, MD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Michelle Petri, MD, MPH; Shivani Garg, MD, PhD

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

Burst CME™: Recognizing Lupus Nephritis—From Timely Diagnosis to Appreciating the Underlying Mechanisms of Disease

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Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

Bridging Regional Challenges in Retinal Disease Management: Applying Advanced Anti-VEGF Therapy in Community Practice - Florida

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The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

Rahul Gosain, MD, MBA; Rohit Gosain, MD

From Suspicion to Stabilization: Early Recognition and Treatment of Paraneoplastic LEMS

From Suspicion to Stabilization: Early Recognition and Treatment of Paraneoplastic LEMS

Charu Aggarwal, MD, MPH, FASCO; Erminia Massarelli, MD, PhD, MS; Ruham Nasany, MD

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