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This Year In Medicine 2025

Opinion|Videos|January 29, 2026

Reflecting on Trial Limitations in GCA: Painting a Future for IL-17A Targeting Therapies

Author(s)Robert Spiera, MD, John Stone, MD, MPH, Anisha Dua, MD, MPH

Episodes in this series

EP. 1 An Overview of Giant Cell Arteritis (GCA): Common Signs and Symptoms

EP. 1 An Overview of Giant Cell Arteritis (GCA): Common Signs and Symptoms

EP. 2 The Underlying Causes of GCA: Environmental and Genetic Factors

EP. 2 The Underlying Causes of GCA: Environmental and Genetic Factors

EP. 3 Current Gaps in Diagnostic Criteria Standards: Key Factors That Inform Diagnostic Decisions

EP. 3 Current Gaps in Diagnostic Criteria Standards: Key Factors That Inform Diagnostic Decisions

EP. 4 Non-Cranial Symptoms in GCA

EP. 4 Non-Cranial Symptoms in GCA

EP. 5 Imaging Modalities for Diagnosing GCA: What Clinicians are Doing in Clinic

EP. 5 Imaging Modalities for Diagnosing GCA: What Clinicians are Doing in Clinic

EP. 6 Discussing the Overlap of Polymyalgia Rheumatica in Patients With GCA

EP. 6 Discussing the Overlap of Polymyalgia Rheumatica in Patients With GCA

EP. 7 Diagnostic Blood Testing in GCA

EP. 7 Diagnostic Blood Testing in GCA

EP. 8 Expert Perspectives on the Reasons for Diagnostic Delay in GCA

EP. 8 Expert Perspectives on the Reasons for Diagnostic Delay in GCA

EP. 9 The Physical and Mental Quality of Life Impacts of GCA

EP. 9 The Physical and Mental Quality of Life Impacts of GCA

EP. 10 Current Standards of Care in GCA Treatment

EP. 10 Current Standards of Care in GCA Treatment

EP. 11 Real-World Complications Using Steroids to Treat GCA

EP. 11 Real-World Complications Using Steroids to Treat GCA

EP. 12 Current Pathway Treatment Targets in GCA

EP. 12 Current Pathway Treatment Targets in GCA

EP. 13 Reflecting on the Trial Landscape in GCA and History of Approved Agents

EP. 13 Reflecting on the Trial Landscape in GCA and History of Approved Agents

EP. 14 Clinical Experience with Tocilizumab and Upadacitinib in GCA Treatment

EP. 14 Clinical Experience with Tocilizumab and Upadacitinib in GCA Treatment

EP. 15 The Trial Design and Interim Results From the GCAptAIN Trial

EP. 15 The Trial Design and Interim Results From the GCAptAIN Trial

EP. 16 Experts Discuss the REPLENISH Trial for Polymyalgia Rheumatica

EP. 16 Experts Discuss the REPLENISH Trial for Polymyalgia Rheumatica

EP. 17 Reflecting on Trial Limitations in GCA: Painting a Future for IL-17A Targeting Therapies

EP. 17 Reflecting on Trial Limitations in GCA: Painting a Future for IL-17A Targeting Therapies

EP. 18 Hope on the Horizon: The Future of GCA Treatment

EP. 18 Hope on the Horizon: The Future of GCA Treatment

This video covers the following questions:

Do these phase 3 results reflect the limitations of IL‑17A as a therapeutic target in GCA, or might issues in trial design, patient selection, or taper regimen explain the discrepancy between Phase II and Phase III outcomes? What role do you see for secukinumab in future GCA treatment?

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