Treatment of Severe Alopecia Areata with JAK Inhibitors

A panelist discusses how their traditional treatment approach for severe alopecia areata typically involved a stepped care pathway beginning with topical and intralesional steroids before progressing to systemic immunosuppressants or immunotherapy, which often yielded inconsistent, temporary, or incomplete hair regrowth results, leaving significant unmet needs for treatments that could provide sustained efficacy, acceptable safety profiles, and therapies specifically developed for this condition rather than repurposed from other dermatologic disorders.