Yuehui Yin, MD1 ? Darshan Dalal, MD, MPH2 ? Yunqing Chen, PhD1 ? Zengchang Liu, MD1 ? Jinjin Wu, MD1 ? Dong Liu, MD1 ? Xianbin Lan, MD1 ? Yin Dai , MD1 ? Li Su, PhD1 ? Zhiyu Ling, MD1 ? Qiang She, PhD

In patients with lone paroxysmal atrial fibrillation (AF) and normal cardiac function, in the absence of hypertension, myocardial infarction, and cardiac insufficiency, perindopril (Aceon) or losartan (Cozaar) and low-dose amiodarone (Cordarone) therapy are more effective in preventing recurrence of AF than low-dose amiodarone alone. Adding losartan or perindopril to amiodarone therapy can inhibit left atrial enlargement.