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Daily Antituberculosis Therapy Superior for Pulmonary TB in PLWH

A daily, 6-month ATT regimen in HIV-positive patients with TB receiving concomitant ART proved superior to an intermittent regimen in terms of efficacy and prevention of ARR.

Heart failure and sudden death in patients with tachycardia-induced cardiomyopathy and recurrent tachycardia

The effects of recurrent tachycardia after resolution of cardiomyopathy have not been thoroughly assessed. We evaluated and followed 24 patients with tachycardia-induced cardiomyopathy for more than 12 years. Our observations showed that patients with tachycardia-induced cardiomyopathy may be at long-term risk for sudden death. Surreptitious cardiomyopathy due to occult ultrastructural changes may persist. It has yet to be determined whether rapid and aggressive rate control would prevent structural damage to risk of sudden cardiac death.

Hypertension in the elderly

More important than the choice of pharmaceutical agent in the treatment of elderly hypertensive patients is the achievement of goal blood pressure. Low-dose diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers are equally effective in reducing cardiovascular end points. Most patients will require 2 or more drugs to achieve target blood pressure, and physicians should feel comfortable prescribing 3 to 4 agents to a significant proportion of patients.

Vodou Baby--the Birth of a Surgeon

A Haitian nurse offered advice: "Keep your textbook nearby".

Direct Every Arena of Your Tax Burden

Empowering Patients with Multiple Sclerosis to Follow Their Own Path to Pain Relief

Coping strategies based on enhanced mindfulness and a greater sense of agency can help patients improve their quality of life.

2018-2019 Flu Vaccine Recommendations from ACIP

New recommendations from the CDC's Advisory Committee on Immunization Practices reveal that health care providers have the intranasally-administered live attenuated influenza vaccine (LAIV) among their arsenal of available vaccines for the 2018-2019 flu season.

The Dark Side of Annuities

Early Momentum for a Genomic Approach to Sickle Cell Disease Therapy

In a late-breaking presentation at ASGCT 2022, investigators shared preclinical results of a gene-editing strategy that seeks to reactivate developmentally silenced fetal hemoglobin (HbF, α2γ2) in order to replace defective sickle hemoglobin (HbS, α2βS2).