Therapeutics, T


Mortality of patients with diabetes mellitus and acute myocardial infarction

We evaluated trends in the treatment and mortality of patients with and without diabetes mellitus and acute myocardial infarction over the last decade. Despite improvements in the provision of evidence-based care, patients with diabetes did not derive improvements in long-term survival.

Cosima Jahnke, MD


Cardiac magnetic resonance stress tests in coronary heart disease

We evaluated the prognostic value of cardiac magnetic resonance (CMR) stress testing with direct comparison of adenosine stress first-pass perfusion and dobutamine stress wall motion imaging among 513 subjects with known or suspected coronary heart disease over a median follow-up period of 2.3 years. Positive results on CMR stress testing identified subjects at high risk for subsequent cardiac events (nonfatal myocardial infarction or cardiac death), whereas normal CMR stress test results were associated with a very low annual cardiac event rate.

Khalil A. Kaid, MD


Double infarct syndrome: Simultaneous subacute ST-segment elevation myocardial infarction involving the right coronary and the left circumflex arteries

Ruptured or vulnerable plaques exist not only at the culprit lesion but also in the whole coronary artery in some acute coronary syndrome (ACS) patients.Goldstein et al found features of instability of nonculprit plaques in nearly 40% of patients by angiography,1 whereas actual rupture in a remote site other than the angiographic culprit lesion was found in approximately 13% to 79% of cases when evaluated by intravascular ultrasound.

Peng Thim Fan, MD


How Should I Manage This Man's Red, Swollen Toe?

Examining the right foot of a 54-year-old male reveals a red, swollen, warm, and exquisitely tender right first toe joint. What is the differential diagnosis?

Alexander S. Asser, MD, fellow, division of cardiology, George Washington University Medical Center, Washington, DC.


Observational study shows risk of death from CVD differs between sexes

The last 2 decades have seen enormous strides in the identifi cation and modification of cardiovascular disease (CVD) risk factors. Many large, population-based studies, led by the Framingham Heart Study, have been invaluable in identifying these risk factors.

Wayne Kuznar


Intensive Medical Therapy Is Reducing the Indications for Carotid Revascularization in Asymptomatic Patients

Intensifying medical therapy would obviate the need for carotid revascularization in all but 4% of patients with asymptomatic carotid stenosis.

David Stukus, MD


Food Allergy Prevention: A Paradigm Shift in How We Feed Our Babies

Rapidly accumulating evidence indicates that delayed introduction of allergenic foods may have contributed to the unexplained rise in food allergy rates over the past 20 years.

John Zoidis, MD


News Reports from the 2007 Breast Cancer Symposium

The first annual 2007 Cancer Symposium, held September 7-8 in San Francisco, provided an opportunity for members of the oncology community to discuss major developments in breast cancer treatment and research.

Bijal Jain


New Therapy for Barrett's Esophagus and Prevention of Esophageal Adenocarcinoma

As you may know, in about 10% of people, the natural history of GERD is progression to Barrett's esophagus, where the normal squamous epithelial lining of the esophagus is displaced by columnar epithelium from the intestine (intestinal metaplasia).

Brad Schmidt


Decrease in Postoperative Delirium in Elderly Patients

Data show that for every 3.5 to 4.7 patients treated with light sedation compared to deep sedation, one incident of delirium will be prevented.

Maria G. Montez, RN, MSHP


Effectiveness and Cost-Effectiveness of Diabetes Prevention among Adherent Participants

Over 10 years, lifestyle intervention and metformin were cost-effective or cost saving compared with placebo.

Anita Ramsetty, MD


Paper or Plastic? For Glucose Logs, That Is...

There have already been some snags and alarms raised in questioning just how successful this new batch of tech toys for diabetes will be in the end.

Ayesha Mian, MD


Tackling Xenophobia: Are We There Yet?

The mental health effects of xenophobia can have far-reaching consequences for children and adolescents.

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