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Experts in pediatric hepatology share considerations for the diagnosis of Alagille syndrome and explore strategies for optimizing treatment.

Updates in the Management of Alagille Syndrome

Episodes

Specialty:

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Year:

All

EP. 1: Overview of Alagille Syndrome (ALGS)

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Philip Rosenthal, MD, leads an overview of Alagille syndrome and discusses the role of genetic testing in the screening and diagnosis of disease.

EP. 2: Clinical Presentation of ALGS

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Drs Ryan T. Fischer, William Balistreri, and Regino Gonzalez-Peralta comment on the clinical variability in the presentation of Alagille syndrome in patients.

EP. 3: Clinical Burden of ALGS for Pediatric Patients

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Regino Gonzalez-Peralta, MD, provides insight on quality-of-life issues for patients and caregivers with Alagille syndrome.

EP. 4: Patient Journey to ALGS Diagnosis

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Philip Rosenthal, MD, discusses his approach to the diagnostic workup for Alagille syndrome.

EP. 5: Clinical Outcomes and Management of ALGS

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Experts in pediatric hepatology review health complications associated with ALGS and the importance of early diagnosis to manage the disease.

EP. 6: Multidisciplinary Management of ALGS

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Regino Gonzalez-Peralta, MD, explores the role of a multidisciplinary approach to the diagnosis and management of patients with Alagille syndrome.

EP. 7: Monitoring Nutrition and Progression of ALGS

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Philip Rosenthal, MD, examines monitoring requirements and follow-ups for patients with Alagille syndrome.

EP. 8: Goals of Therapy for ALGS

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Jennifer M. Vittorio, MD, reviews goals of therapy from early disease through progression of Alagille syndrome.

EP. 9: Individualizing Treatment Approaches for ALGS Management

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Drs Ryan T. Fischer and Regino Gonzalez-Peralta highlight the importance of tailoring treatment to a patient’s symptoms and define treatment success for Alagille syndrome.

EP. 10: Treating Persistent Pruritus for ALGS

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Jennifer M. Vittorio, MD, leads a discussion on initial treatment approaches and new drugs on the horizon for the management of persistent pruritus in patients with Alagille syndrome.

EP. 11: Using Maralixibat for the Management of Pediatric ALGS

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Regino Gonzalez-Peralta, MD, reviews clinical implications from the phase 2 ICONIC trial evaluating the use of maralixibat for the management of Alagille syndrome in pediatric patients.

EP. 12: Unmet Needs and Novel Agents for the Management of ALGS

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Jennifer M. Vittorio, MD, and Philip Rosenthal, MD, comment on remaining challenges for the management of patients with Alagille syndrome and discuss novel therapeutic agents under investigation for disease management.

EP. 13: Patient Education and Future Directions for ALGS Management

ByWilliam F. Balistreri, MD,Philip Rosenthal, MD,Jennifer M. Vittorio, MD,Ryan T. Fischer, MD,Regino P. Gonzalez-Peralta, MD

June 14th 2022

Drs Ryan T. Fischer and Regino Gonzalez-Peralta provide insight on educating patients and their caregivers on emerging treatment options for Alagille syndrome and the potential impact of evolving therapies on the progression of liver disease.