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Spotlight -

This Year In Medicine 2025

Opinion|Videos|February 4, 2025

IL-13–Targeting Agents in Atopic dermatitis

Author(s)Linda Stein Gold, MD, Alexandra K. Golant, MD, Peter Lio, MD

Panelists discuss the differences between the 3 FDA-approved IL-13–targeting agents for atopic dermatitis (AD)—dupilumab, tralokinumab, and lebrikizumab—and how these differences in their mechanisms of action might impact their effectiveness in targeting the disease and addressing various patient needs.

Episodes in this series

EP. 1 Heterogenous Presentation Of Atopic Dermatitis

EP. 1 Heterogenous Presentation Of Atopic Dermatitis

EP. 2 Use of Biopsy and Diagnosing New-Onset AD

EP. 2 Use of Biopsy and Diagnosing New-Onset AD

EP. 3 Treatment Options in Atopic Dermatitis

EP. 3 Treatment Options in Atopic Dermatitis

EP. 4 Improvement in Standard of Care in Atopic Dermatitis

EP. 4 Improvement in Standard of Care in Atopic Dermatitis

EP. 5 Improvement in Patients’ Qualify of Life with Atopic Dermatitis Treatments

EP. 5 Improvement in Patients’ Qualify of Life with Atopic Dermatitis Treatments

EP. 6 Guidance for Moving to Advanced Systemic Therapy and Biologic Agents

EP. 6 Guidance for Moving to Advanced Systemic Therapy and Biologic Agents

EP. 7 IL-13–Targeting Agents in Atopic dermatitis

EP. 7 IL-13–Targeting Agents in Atopic dermatitis

EP. 8 Efficacy Data With IL-13 Targeting Agents in Atopic Dermatitis

EP. 8 Efficacy Data With IL-13 Targeting Agents in Atopic Dermatitis

EP. 9 Less Frequent Administration of Lebrikizumab for Atopic Dermatitis

EP. 9 Less Frequent Administration of Lebrikizumab for Atopic Dermatitis

EP. 10 Switching or Staying Within the Treatment Class

EP. 10 Switching or Staying Within the Treatment Class

EP. 11 Use of Combination Therapy in Atopic Dermatitis

EP. 11 Use of Combination Therapy in Atopic Dermatitis

EP. 12 Safety Data With Biologics in Atopic Dermatitis

EP. 12 Safety Data With Biologics in Atopic Dermatitis

EP. 13 Data With IL-13– Targeting Agents in Atopic Dermatitis in Clinical Practice

EP. 13 Data With IL-13– Targeting Agents in Atopic Dermatitis in Clinical Practice

EP. 14 Lebrikizumab in Patients With Skin of Color (ADmirable)

EP. 14 Lebrikizumab in Patients With Skin of Color (ADmirable)

EP. 15 Treatment Nonresponders in Atopic Dermatitis

EP. 15 Treatment Nonresponders in Atopic Dermatitis

EP. 16 Considerations for Switching Treatment

EP. 16 Considerations for Switching Treatment

EP. 17 Emerging Treatment Options in Atopic Dermatitis

EP. 17 Emerging Treatment Options in Atopic Dermatitis

Video content above is prompted by the following:

There are 3 IL-13–targeting agents that are FDA-approved for treatment of AD (dupilumab, tralokinumab, and lebrikizumab).
How do they differ from each other?
How might these differences impact how these drugs target the disease?

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