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This Year In Medicine 2025

Opinion|Videos|May 8, 2024

Innovations in Small Interfering RNA (siRNA) Therapy

Author(s)Pam Taub, MD, FACC, FASPC, Michael Koren, MD, FACC , Erin D. Michos, MD, MHS

Leading experts highlight the established role of PCSK9 inhibitors, such as evolocumab and alirocumab, and introduce the promising second-generation PCSK9 inhibitors, known as small interfering RNA (siRNA), which represent an innovative therapeutic approach that selectively reduces the production of specific proteins through RNA interference.

Episodes in this series

Video 1 - "Overview of Low-Density Lipoprotein Cholesterol Management"

EP. 1 Overview of Low-Density Lipoprotein Cholesterol Management

Video 2 - "Stricter LDL-C Targets: Explaining Goalpost Changes to Patients"

EP. 2 Stricter LDL-C Targets: Explaining Goalpost Changes to Patients

Video 3 - "Ongoing Lp(a) Trials and Clinical Approaches to Treatment"

EP. 3 Ongoing Lp(a) Trials and Clinical Approaches to Treatment

Video 4 - "Innovations in Small Interfering RNA (siRNA) Therapy"

EP. 4 Innovations in Small Interfering RNA (siRNA) Therapy

Video 5 - "Optimizing PCSK9 Inhibitors and Analyzing Plaque Reduction Data"

EP. 5 Optimizing PCSK9 Inhibitors and Analyzing Plaque Reduction Data

Video 6 - "Evaluating Safety of Novel LDL Management Mechanism"

EP. 6 Evaluating Safety of Novel LDL Management Mechanism

A panel of 5 cardiovascular experts

EP. 7 Examining Results from VICTORION-INITIATE Trial

A panel of 5 cardiovascular experts

EP. 8 Other Notable Emerging Lipid-Lowering Treatments

A panel of 5 cardiovascular experts

EP. 9 REDUCE-IT Trial and Triglyceride-Lowering Agents

A panel of 5 cardiovascular experts

EP. 10 Diabetes, GLP-1, and Lipid Reduction

A panel of 5 cardiovascular experts

EP. 11 Medication Adherence in Patients with High LDL Cholesterol

A panel of 5 cardiovascular experts

EP. 12 Overcoming Prior Authorization Barriers in LDL Cholesterol Therapies

A panel of 5 cardiovascular experts

EP. 13 Cardiometabolic Medicine: Seeing the Patient as a Whole

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