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This Year In Medicine 2025

Opinion|Videos|November 18, 2024

Real-World Clinical Experience With JAK Inhibitors

Author(s)Arash Mostaghimi, MD, MPH, Amy McMichael, MD, Brittany G. Craiglow, MD

Key Takeaways

JAK inhibitors offer a novel approach for alopecia treatment, with varying outcomes and tolerability among different agents observed by clinicians.
Systemic JAK inhibitors provide advantages over traditional therapies, including targeted action and potential efficacy in severe alopecia cases.
Considerations regarding side effects and long-term safety are crucial when using systemic JAK inhibitors for alopecia treatment.
The choice of JAK inhibitor may depend on individual patient factors, including previous treatment responses and specific alopecia subtype.

SHOW MORE

Panelists discuss their clinical experiences with Janus kinase (JAK) inhibitors for treating alopecia, noting observed differences in outcomes and tolerability among various systemic JAK inhibitors, while highlighting the advantages of these therapies over traditional local and systemic treatment options.

Episodes in this series

EP. 1 Impact of Alopecia Areata on Quality of Life, and Current Standard of Treatment

EP. 1 Impact of Alopecia Areata on Quality of Life, and Current Standard of Treatment

EP. 2 JAK Inhibitor Baricitinib for Treatment of Alopecia Areata

EP. 2 JAK Inhibitor Baricitinib for Treatment of Alopecia Areata

EP. 3 Analyzing Phase 3 Clinical Trial Data of Baricitinib in Alopecia Areata

EP. 3 Analyzing Phase 3 Clinical Trial Data of Baricitinib in Alopecia Areata

EP. 4 Novel Mechanisms of Action for Treatment of Alopecia Areata

EP. 4 Novel Mechanisms of Action for Treatment of Alopecia Areata

EP. 5 Physician and Patient Communication for the Management of Alopecia Areata

EP. 5 Physician and Patient Communication for the Management of Alopecia Areata

EP. 6 Recent Advances in the Treatment of Alopecia Areata

EP. 6 Recent Advances in the Treatment of Alopecia Areata

EP. 7 The Pathophysiology of Alopecia Areata

EP. 7 The Pathophysiology of Alopecia Areata

EP. 8 The Benefits of Early Diagnosis of Alopecia Areata

EP. 8 The Benefits of Early Diagnosis of Alopecia Areata

EP. 9 Patient Factors and Other Considerations for Treatment Selection

EP. 9 Patient Factors and Other Considerations for Treatment Selection

EP. 10 Treatment Options for Alopecia Areata

EP. 10 Treatment Options for Alopecia Areata

EP. 11 Review of FDA Approved JAK Inhibitors for Alopecia Areata

EP. 11 Review of FDA Approved JAK Inhibitors for Alopecia Areata

EP. 12 JAK Inhibition in the Treatment of Alopecia Areata

EP. 12 JAK Inhibition in the Treatment of Alopecia Areata

EP. 13 Assessing Risk and Safety of JAK Inhibitors

EP. 13 Assessing Risk and Safety of JAK Inhibitors

EP. 14 Real-World Clinical Experience With JAK Inhibitors

EP. 14 Real-World Clinical Experience With JAK Inhibitors

EP. 15 Challenges With the Use of JAK Inhibitors

EP. 15 Challenges With the Use of JAK Inhibitors

EP. 16 Considerations Regarding Patient Selection for JAK Inhibitors

EP. 16 Considerations Regarding Patient Selection for JAK Inhibitors

EP. 17 The Role of Health Care Providers in Raising Awareness About Alopecia Areata

EP. 17 The Role of Health Care Providers in Raising Awareness About Alopecia Areata

EP. 18 Future Directions in the Treatment of Alopecia Areata

EP. 18 Future Directions in the Treatment of Alopecia Areata

Video content above is prompted by the following:

What has been your clinical experience with JAK inhibitors for treatment of alopecia?

a. Have you observed differences in outcomes and/or tolerability with using different systemic JAK inhibitors?

What are the advantages of using systemic JAK inhibitor therapies compared with traditional local or systemic therapies?

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