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This Year In Medicine 2025

Opinion|Videos|November 25, 2024

Considerations Regarding Patient Selection for JAK Inhibitors

Author(s)Arash Mostaghimi, MD, MPH, Amy McMichael, MD, Brittany G. Craiglow, MD

Key Takeaways

JAK inhibitors are effective for moderate to severe alopecia, especially in patients unresponsive to conventional therapies.
Ideal candidates are those with significant hair loss affecting quality of life.
Caution is necessary for patients with malignancies, active infections, or immunocompromised status due to immune modulation.
Patients with thromboembolic history or cardiovascular risks need thorough evaluation before treatment initiation.

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Episodes in this series

EP. 1 Impact of Alopecia Areata on Quality of Life, and Current Standard of Treatment

EP. 1 Impact of Alopecia Areata on Quality of Life, and Current Standard of Treatment

EP. 2 JAK Inhibitor Baricitinib for Treatment of Alopecia Areata

EP. 2 JAK Inhibitor Baricitinib for Treatment of Alopecia Areata

EP. 3 Analyzing Phase 3 Clinical Trial Data of Baricitinib in Alopecia Areata

EP. 3 Analyzing Phase 3 Clinical Trial Data of Baricitinib in Alopecia Areata

EP. 4 Novel Mechanisms of Action for Treatment of Alopecia Areata

EP. 4 Novel Mechanisms of Action for Treatment of Alopecia Areata

EP. 5 Physician and Patient Communication for the Management of Alopecia Areata

EP. 5 Physician and Patient Communication for the Management of Alopecia Areata

EP. 6 Recent Advances in the Treatment of Alopecia Areata

EP. 6 Recent Advances in the Treatment of Alopecia Areata

EP. 7 The Pathophysiology of Alopecia Areata

EP. 7 The Pathophysiology of Alopecia Areata

EP. 8 The Benefits of Early Diagnosis of Alopecia Areata

EP. 8 The Benefits of Early Diagnosis of Alopecia Areata

EP. 9 Patient Factors and Other Considerations for Treatment Selection

EP. 9 Patient Factors and Other Considerations for Treatment Selection

EP. 10 Treatment Options for Alopecia Areata

EP. 10 Treatment Options for Alopecia Areata

EP. 11 Review of FDA Approved JAK Inhibitors for Alopecia Areata

EP. 11 Review of FDA Approved JAK Inhibitors for Alopecia Areata

EP. 12 JAK Inhibition in the Treatment of Alopecia Areata

EP. 12 JAK Inhibition in the Treatment of Alopecia Areata

EP. 13 Assessing Risk and Safety of JAK Inhibitors

EP. 13 Assessing Risk and Safety of JAK Inhibitors

EP. 14 Real-World Clinical Experience With JAK Inhibitors

EP. 14 Real-World Clinical Experience With JAK Inhibitors

EP. 15 Challenges With the Use of JAK Inhibitors

EP. 15 Challenges With the Use of JAK Inhibitors

EP. 16 Considerations Regarding Patient Selection for JAK Inhibitors

EP. 16 Considerations Regarding Patient Selection for JAK Inhibitors

EP. 17 The Role of Health Care Providers in Raising Awareness About Alopecia Areata

EP. 17 The Role of Health Care Providers in Raising Awareness About Alopecia Areata

EP. 18 Future Directions in the Treatment of Alopecia Areata

EP. 18 Future Directions in the Treatment of Alopecia Areata

Video content above is prompted by the following:

What is the ideal patient population for use of JAK inhibitors for alopecia?

Are there certain patient characteristics that would compel you to not use JAK inhibitors?

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