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This Year In Medicine 2025

Opinion|Videos|November 25, 2024

Challenges With the Use of JAK Inhibitors

Author(s)Arash Mostaghimi, MD, MPH, Amy McMichael, MD, Brittany G. Craiglow, MD

Key Takeaways

Patient selection is critical, as response to oral JAK inhibitors varies among individuals with alopecia.
Monitoring for side effects, including infection risk and blood count changes, is essential for safe use.
Limited long-term safety data necessitates cautious use and further research into oral JAK inhibitors.
Cost and insurance coverage challenges can hinder patient access to these treatments.

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Episodes in this series

EP. 1 Impact of Alopecia Areata on Quality of Life, and Current Standard of Treatment

EP. 1 Impact of Alopecia Areata on Quality of Life, and Current Standard of Treatment

EP. 2 JAK Inhibitor Baricitinib for Treatment of Alopecia Areata

EP. 2 JAK Inhibitor Baricitinib for Treatment of Alopecia Areata

EP. 3 Analyzing Phase 3 Clinical Trial Data of Baricitinib in Alopecia Areata

EP. 3 Analyzing Phase 3 Clinical Trial Data of Baricitinib in Alopecia Areata

EP. 4 Novel Mechanisms of Action for Treatment of Alopecia Areata

EP. 4 Novel Mechanisms of Action for Treatment of Alopecia Areata

EP. 5 Physician and Patient Communication for the Management of Alopecia Areata

EP. 5 Physician and Patient Communication for the Management of Alopecia Areata

EP. 6 Recent Advances in the Treatment of Alopecia Areata

EP. 6 Recent Advances in the Treatment of Alopecia Areata

EP. 7 The Pathophysiology of Alopecia Areata

EP. 7 The Pathophysiology of Alopecia Areata

EP. 8 The Benefits of Early Diagnosis of Alopecia Areata

EP. 8 The Benefits of Early Diagnosis of Alopecia Areata

EP. 9 Patient Factors and Other Considerations for Treatment Selection

EP. 9 Patient Factors and Other Considerations for Treatment Selection

EP. 10 Treatment Options for Alopecia Areata

EP. 10 Treatment Options for Alopecia Areata

EP. 11 Review of FDA Approved JAK Inhibitors for Alopecia Areata

EP. 11 Review of FDA Approved JAK Inhibitors for Alopecia Areata

EP. 12 JAK Inhibition in the Treatment of Alopecia Areata

EP. 12 JAK Inhibition in the Treatment of Alopecia Areata

EP. 13 Assessing Risk and Safety of JAK Inhibitors

EP. 13 Assessing Risk and Safety of JAK Inhibitors

EP. 14 Real-World Clinical Experience With JAK Inhibitors

EP. 14 Real-World Clinical Experience With JAK Inhibitors

EP. 15 Challenges With the Use of JAK Inhibitors

EP. 15 Challenges With the Use of JAK Inhibitors

EP. 16 Considerations Regarding Patient Selection for JAK Inhibitors

EP. 16 Considerations Regarding Patient Selection for JAK Inhibitors

EP. 17 The Role of Health Care Providers in Raising Awareness About Alopecia Areata

EP. 17 The Role of Health Care Providers in Raising Awareness About Alopecia Areata

EP. 18 Future Directions in the Treatment of Alopecia Areata

EP. 18 Future Directions in the Treatment of Alopecia Areata

Video content above is prompted by the following:

What challenges have you faced, if any, in using oral JAK inhibitors for patients with alopecia?

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