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This Year In Medicine 2025

Opinion|Videos|May 23, 2025

The Future of Chronic Hand Eczema Treatment

Author(s)Raj Chovatiya, MD, PhD

An expert discusses how new treatments for chronic hand eczema (CHE) are emerging, particularly topical delgocitinib cream, a pan-Janus kinase (JAK) inhibitor that shows promise for treating multiple etiologies of the condition without the limitations of traditional topical steroids.

Episodes in this series

1 expert in this video

EP. 1 Prevalence, Presentation, and the CHE Patient Journey

1 expert in this video

EP. 2 CHE Subtypes

1 expert in this video

EP. 3 Risk Factors of CHE

1 expert in this video

EP. 4 CHE: Symptoms and Diagnosis

1 expert in this video

EP. 5 Impact of CHE on Patient Quality of Life

1 expert in this video

EP. 6 Current Treatments Options for Patients With CHE

1 expert in this video

EP. 7 The Future of Chronic Hand Eczema Treatment

Video content above is prompted by the following:

Future Directions of CHE Treatment

Key Themes:

Emerging therapies: Topical delgocitinib cream, a pan-JAK inhibitor, shows promise specifically for CHE.
Other investigational options: Topical ruxolitinib, dupilumab, and tralokinumab have shown efficacy in certain CHE populations.
Clinical approach: Avoiding treatment delays while pursuing diagnostic workup, with consideration for targeted therapies across multiple etiologies.

Notable Insights:

Dr Chovatiya emphasized that "having a cream that can help patients across etiologies and not delay their actual treatment represents a huge potential win for us in dermatology," suggesting a paradigm shift in CHE management.

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