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This Year In Medicine 2025

Opinion|Videos|May 9, 2025

CHE: Symptoms and Diagnosis

Author(s)Raj Chovatiya, MD, PhD

An expert discusses how chronic hand eczema (CHE) diagnosis relies on clinical features such as erythema, scaling, vesicles, hyperkeratosis, fissures, and erosions, which must be distinguished from atopic dermatitis through a comprehensive patient history and full-body examination.

Episodes in this series

1 expert in this video

EP. 1 Prevalence, Presentation, and the CHE Patient Journey

1 expert in this video

EP. 2 CHE Subtypes

1 expert in this video

EP. 3 Risk Factors of CHE

1 expert in this video

EP. 4 CHE: Symptoms and Diagnosis

1 expert in this video

EP. 5 Impact of CHE on Patient Quality of Life

1 expert in this video

EP. 6 Current Treatments Options for Patients With CHE

1 expert in this video

EP. 7 The Future of Chronic Hand Eczema Treatment

Video content above is prompted by the following:

CHE Clinical Features and Diagnosis

Key Themes:

Key clinical signs: Erythema, scaling, edema, vesicles, hyperkeratosis, fissures, and erosions, with more chronic than acute presentation.
Differential diagnosis: Distinguishing CHE from atopic dermatitis requires a holistic history and full-body examination.
Predominant symptoms: Beyond itching, skin pain represents a significant burden, particularly from fissures and cracking.

Notable Insights:

Dr Chovatiya emphasized that "from a patient perspective...a focus on skin pain as well as some of the cracking, bleeding, opening of skin, and wounding is going to be extraordinarily vital to really understanding the patient’s perspective."

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