mRNA Gene Therapy is More Cost-Efficient for Treating Inherited Retinal Diseases
December 7th 2023Gene therapy with mRNA is more cost-efficient, has a better safety profile, and is more reproducible than the viral vector, AAV, currently used for gene therapy to improve inherited retinal diseases.
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Pooled Analysis Supports Bioequivalence Between MB02 and Reference Bevacizumab
December 5th 2023In a new pooled analysis of 3 pharmacokinetic studies, the investigators confirmed the bioequivalence, safety, and immunogenicity between biosimilar MB02 and European Union approved bevacizumab and US-approved bevacizumab.
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Patients Unsatisfied After Mandatory Adalimumab Biosimilar Transition
December 5th 2023Aotearoa, New Zealand had a mandatory adalimumab biosimilar transition from March – September 2022. A survey reveals low satisfaction with biosimilar’s quality, as well as the lack of alcoholic wipes and a support program.
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CBT Linked to Improving Depression Symptoms in Adults with Type 1 Diabetes
December 4th 2023In a new study focusing on adults with type 1 diabetes and mild-moderate depressive symptomatology, a CBT program helped depression symptoms, quality of life, anxiety, treatment adherence, and total diabetes-related stress in emotional, physical, and impersonal subscales.
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Mothers’ Mental Disorders Is Not Linked to Type 1 Diabetes in Offspring
December 4th 2023Mothers with mood disorders—either bipolar disorder, major depressive disorder— or schizophrenia/ schizoaffective disorder are not associated with their offspring’s risk for type 1 diabetes. Results suggest mothers with bipolar disorder tend to develop type 1 diabetes, but data is not clinically significant.
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Lower Sleep Efficiency Linked to Higher HbA1c in Adolescents with Type 1 Diabetes
December 2nd 2023The study did not find an association between glycemic parameters and flow-mediated dilation, but they did find associations between lower sleep efficiency with poorer glycemic control, insulin resistance, estimated glucose disposal rate, and HbA1C.
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FDA Accepts Xanomeline-Trospium Drug Application for Schizophrenia Treatment
November 29th 2023The FDA will decide on the approval of xanomeline-trospium, a dual M1/M4 muscarinic acetylcholine receptor agonist in the central nervous system, for the treatment of schizophrenia patients by September 2024.
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In a new study, the highest socioeconomic group was associated with lower morality rates for all-cause mortality, lower morality from natural causes, and higher mortality from external causes. Although the data does not show a significant link between the role of socioeconomic position with the mortality rate among people with mental disorders.
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COVID-19 Vaccine Safe for Patients with Hepatitis C Virus-Related Liver Disease
November 22nd 2023After receiving the COVID-19 vaccination, the antibody titers of patients with cirrhosis and hepatocellular carcinoma were significantly reduced compared to patients with chronic hepatitis C patients.
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Smartphone Notifications Helps Prevent Missed Doses for Gout Medication
November 20th 2023The 2 groups—the active control group who received smartphone notifications about general health advice and the intervention group who receive notifications on adherence-targeted information—did not have significant differences in serum urate levels.
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Low-Cost Standard-Field Fundus Camera Viable for Proliferative Sickle Cell Retinopathy Screening
November 18th 2023Standard-Field Fundus Camera performs well in detecting proliferative sickle cell retinopathy, but performs poorly detecting non-proliferative sickle cell retinopathy, a new study found.
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Vision Impairment Associated with Developing Mental Health Conditions
November 17th 2023After years 1, 3, and 5, patients with diabetic retinopathy patients had increased odds of depression and suicide, patients with glaucoma had increased odds for all mental health conditions with higher odds for suicide or suicide ideation, and patients with AMD had increased odds for depression.
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