Semaglutide Does Not Worsen Diabetic Retinopathy Status
Despite recommendations to consult with ophthalmologists prior to initiating semaglutide, the cardiometabolic drug was not found to be linked to worsened DR outcomes.
SGLT-2 Inhibitors Reduce Glaucoma Risk in Type 2 Diabetes Patients
New AAO 2023 data suggests drugs like dapagliflozin and empagliflozin may provide greater protection against glaucoma than GLP-1 agonists or DDP-4 inhibitors.
Switching to Faricimab Improves nAMD Dryness, Reduces Treatment Burden
New data from the Cleveland Clinic Cole Eye Institute showed patients not responding to anti-VEGF inhibitors could improve clinical and regimen parameters with short-term faricimab.
FDA Approves Secukinumab for Hidradenitis Suppurativa
Secukinumab (Cosentyx) becomes the first IL-17A inhibitor, as well as the first drug since 2015, approved to treat adults with moderate to severe HS.
Andreas Kremer, MD, PhD, MHBA: Seladelpar for the Treatment of PBC
Kremer discusses new ad hoc findings from the phase 3 ENHANCE trial showing seladelpar's unique effect on pruritus in patients with PBC.
Etrasimod Significantly Benefits Ulcerative Colitis Regardless of Corticosteroids
New data from ACG 2023 shows etrasimod-treated patients were able to achieve UC remission, with or without concomitant steroid treatment at baseline.
Guselkumab Benefits Ulcerative Colitis Regardless of Patient Treatment History
New QUASAR analysis shows patients with intolerance or failed response to advanced therapies nonetheless achieved benefit with guselkumab.
Better Fecal Live Microbiota Outcomes Linked to Gut Microbiome Health
New PUNCH CD3 analyses show patients who were treated with live fecal microbiota therapy improved their gut health at 8 weeks—which correlated with improved quality-of-life scores.
Paul Feuerstadt, MD: Preventing Recurrent C Difficile in Older Adults with Comorbidities
Feuerstadt reviews ACG 2023 data showing live microbiota therapy provides consistent protection against rCDI in one of the most vulnerable patient populations.
Autoimmune Hepatitis at ACG 2023, with Gina Choi, MD
The UCLA hepatologist discusses the current treatment landscape, prospects for improved diagnostics, and the overlap syndrome live from ACG 2023.
Uma Mahadevan, MD: Prioritizing Gastric Health in Gestational Patients
The investigator discusses the unique interplay between conditions like IBD and gestational risks—and how specialists need to improve communication.
Brian Lacy, MD, PhD: Tailoring Treatment Experiences for IBS-C Patients
No catch-all drug works to treat irritable bowel syndrome with constipation. But as the Mayo Clinic expert explains, enough unique options exist to tailor care better than ever.
Gestational Low-Dose Aspirin Does Not Increase Risk of IBD Flares in Women
Study author Uma Mahadevan, MD, discusses her team's findings suggesting the concern of IBD flare risk in pregnant women receiving aspirin to prevent preeclampsia is unwarranted.
Jiten P. Kothadia, MD: Using S-DAT to Reduce Alcohol Liver Disease Relapses
The study author discusses the clinical implications of his team's assessment into a risk factor score for alcohol relapse among post-transplant patients with ALD.
Tenapanor Provides Varied Timing for IBS-C Symptom Relief
Investigator Brian E. Lacy, MD, PhD discusses new post hoc analysis that he hopes will provided clearer expectations for timing of benefit with tenapanor.
S-DAT Score Predictive of Alcohol Relapse Risk in Liver Transplant Patients
Investigator Jiten P. Kothadia, MD, discusses the advent of a predictive score for alcohol relapse risk in patients with alcohol liver disease who received a liver transplant in the last year.
Next-Generation Cologuard Improves Colorectal Cancer Detection, False Positive Rates in BLUE-C
Thomas F. Imperiale, MD, discusses the pivotal findings showing improvements to the prior iteration of Cologuard, as well as bettered sensitivity and specificty relative to fecal immunochemical tests.
Ryan A. Smith, MD: RSV Risk in Patients with IBD
Data presented at ACG 2023 shows a significantly increased risk of infection and hospitalization due to RSV in patients with IBD. An investigator discusses implications during an era of increased vaccine options.
Oral Biotherapeutic ADS024 Safe, Tolerable for Recurrent C difficile Prevention
New phase 1b data supports further investigation into Adiso Therapeutic's prospective treatment.
Live Microbiota Therapy Prevents Recurrent CDI in Older Adults with Comorbidity
New data presented at ACG 2023 showed an approximate 60% success rate of recurrent C difficile prevention in adults with comorbid conditions including CKD and cardiac disease.
FDA Approves IDP-126 (Cabtreo), First Triple-Combination Drug for Acne
Designed to treat the acne's inflammation, bacteria and follicular hyperkeratinization, IDP-126 has shown significant efficacy compared to standard-care options already on the market.
Regeneron, Sanofi Receive CRL for Add-On Dupilumab sBLA for Chronic Spontaneous Urticaria
The latest indication for the dual inflammatory pathway-targeting biologic expands dupilumab's clinical availability to third chronic skin disease.
FDA Approves Bimekizumab for Adults with Plaque Psoriasis
The approval for the IL-17A and IL-17F inhibitor is supported by data showing about 80% of patients achieved nearly clear skin within 4 doses.
Rene Gomez-Esquivel, MD: Screening for Pediatric Colon Cancer
Though rare, pediatric colon cancer often presents in advanced stages—emphasizing the need for awareness of risk factors and the opportunities borne from timely intervention.
Nancy Reau, MD: Larsucosterol for Alcohol-Associated Hepatitis
Phase 2b data from the AHFIRM trial is anticipated soon. Reau discusses what the agent may show in treating alcohol-associated hepatitis.
Michele H. Maddux, PhD: Mental and Behavioral Health in Pediatric IBD
The role of psychiatric care may be understated in treating IBD in children and adolescents nearing adult age.
FDA Denies Marketing to 6 Vuse Alto Flavored E-Cigarette Products
The marketing denial orders were due to what the FDA stated as insufficient data supporting the products' additional benefit for adults switching from smoking cigarettes to vaping or cessation.
Rene Esquivel Gomez, MD: Pediatric Endoscopy and Colonoscopy Strategies
Slight differences in disease presentation, as well as navigating the safety discussion with parents, presents unique recommendations for pediatricians initiating invasive imaging.
Survey Highlights Pediatrician Strategies for Cow Milk-Allergic Infants During Formula Shortage
Data show how care providers shifted their mindsets to prioritize efficacy, safety, tolerability and availability factors during the 2022 formula supply shortage and recall crises.
Tegan Medico, MS, MPH, RDN, CNSC: Diet and Nutrition Management in Pediatric Gastric Disease
The optimization of diet and nutrition support during pediatric patients’ rehabilitation is a strategy in lieu of a comprehensively ideal guideline and requires an appreciation for the individual.
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