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This Year In Medicine 2025

Opinion|Videos|March 8, 2025

Challenges for Making a Timely GPP Diagnosis

Author(s)Aaron Farberg, MD, FAAD , Harrison Nguyen, MD, MBA, MPH, FAAD , Boni Elewski, MD, FAAD

Panelists discuss the biggest challenges dermatologists face in diagnosing generalized pustular psoriasis (GPP), focusing on the heterogeneity of patient presentations and how this complicates the diagnosis. They also explore how the relative rarity of GPP, compared with other psoriatic conditions, contributes to delays in diagnosis and treatment. They also examine the impact of misdiagnosis or delayed diagnosis on patient outcomes.

Video content above is prompted by the following:

Episodes in this series

EP. 1 Clinical Presentation and Burden of Disease of Generalized Pustular Psoriasis

EP. 1 Clinical Presentation and Burden of Disease of Generalized Pustular Psoriasis

EP. 2 Impact of GPP Triggers and Flares on a Patient’s Physical and Mental Health

EP. 2 Impact of GPP Triggers and Flares on a Patient’s Physical and Mental Health

EP. 3 Approaches to Diagnosing GPP and Distinguishing It From Other Psoriatic Conditions

EP. 3 Approaches to Diagnosing GPP and Distinguishing It From Other Psoriatic Conditions

EP. 4 Challenges for Making a Timely GPP Diagnosis

EP. 4 Challenges for Making a Timely GPP Diagnosis

EP. 5 GPP Pathogenesis and Treatment Goals

EP. 5 GPP Pathogenesis and Treatment Goals

EP. 6 Older Treatment Approaches to GPP Management

EP. 6 Older Treatment Approaches to GPP Management

EP. 7 Addressing the Psychosocial Aspects of GPP Management and the Role of Multidisciplinary Care

EP. 7 Addressing the Psychosocial Aspects of GPP Management and the Role of Multidisciplinary Care

EP. 8 Role of IL-36 in GPP Pathogenesis and Treatment

EP. 8 Role of IL-36 in GPP Pathogenesis and Treatment

EP. 9 Overview of Spesolimab for Management of GPP

EP. 9 Overview of Spesolimab for Management of GPP

EP. 10 Utilizing Intravenous and Subcutaneous Formulations of Spesolimab

EP. 10 Utilizing Intravenous and Subcutaneous Formulations of Spesolimab

EP. 11 Future Directions for GPP Management and Key Takeaways

EP. 11 Future Directions for GPP Management and Key Takeaways

What are some of the biggest challenges dermatologists face when diagnosing GPP?
How does the heterogeneity of patient presentation complicate diagnosis?
Compared with other psoriatic conditions, how does the relative rarity of GPP contribute to delays in diagnosis and treatment?

How can misdiagnosis or delayed diagnosis affect patient outcomes?

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