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Spotlight -

This Year In Medicine 2025

Opinion|Videos|November 26, 2025

Challenges with Current Psoriasis Therapies

Author(s)Christopher G. Bunick, MD, PhD, April W. Armstrong, MD, MPH

Experts discuss the future of psoriasis treatment, highlighting the potential of oral therapies to enhance patient adherence and quality of life.

Episodes in this series

EP. 1 Cytokine Pathways and Their Impact on Plaque Psoriasis

EP. 1 Cytokine Pathways and Their Impact on Plaque Psoriasis

EP. 2 Current Standard of Care and Treatment Options in Psoriasis

EP. 2 Current Standard of Care and Treatment Options in Psoriasis

EP. 3 Role of Mechanisms of Action in Treatment Decisions and Personalized Care in Psorias

EP. 3 Role of Mechanisms of Action in Treatment Decisions and Personalized Care in Psorias

EP. 4 Challenges with Current Psoriasis Therapies

EP. 4 Challenges with Current Psoriasis Therapies

EP. 5 Therapeutic Potential of TYK2 Inhibition in Psoriasis

EP. 5 Therapeutic Potential of TYK2 Inhibition in Psoriasis

EP. 6 Selectivity of TYK2 Inhibition in Psoriasis

EP. 6 Selectivity of TYK2 Inhibition in Psoriasis

EP. 7 Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

EP. 7 Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

EP. 8 Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

EP. 8 Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

EP. 9 Opportunities for TYK2 Inhibition in Moderate Psoriasis

EP. 9 Opportunities for TYK2 Inhibition in Moderate Psoriasis

EP. 10 Other Emerging TYK2 Inhibitors in Psoriasis

EP. 10 Other Emerging TYK2 Inhibitors in Psoriasis

EP. 11 Therapeutic Potential of TYK2 Inhibition in Psoriatic Arthritis

EP. 11 Therapeutic Potential of TYK2 Inhibition in Psoriatic Arthritis

EP. 12 Shared Decision-Making Strategies with TYK2 Inhibition and Future Direction in Psoriasis Care

EP. 12 Shared Decision-Making Strategies with TYK2 Inhibition and Future Direction in Psoriasis Care

Panelists discuss the questions below in this video.

What are the biggest challenges you face with current psoriasis therapies in terms of durability, access, and adherence? What limitations do providers and patients face with therapies such as biologics or oral small molecules, and what quality of life concerns remain inadequately addressed by current therapies?

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