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This Year In Medicine 2025

Opinion|Videos|December 5, 2025

Selectivity of TYK2 Inhibition in Psoriasis

Author(s)Christopher G. Bunick, MD, PhD, April W. Armstrong, MD, MPH

Next-generation TIC-2 inhibitors show remarkable selectivity, enhancing efficacy while minimizing side effects, offering insights into immune system safety.

Episodes in this series

EP. 1 Cytokine Pathways and Their Impact on Plaque Psoriasis

EP. 1 Cytokine Pathways and Their Impact on Plaque Psoriasis

EP. 2 Current Standard of Care and Treatment Options in Psoriasis

EP. 2 Current Standard of Care and Treatment Options in Psoriasis

EP. 3 Role of Mechanisms of Action in Treatment Decisions and Personalized Care in Psorias

EP. 3 Role of Mechanisms of Action in Treatment Decisions and Personalized Care in Psorias

EP. 4 Challenges with Current Psoriasis Therapies

EP. 4 Challenges with Current Psoriasis Therapies

EP. 5 Therapeutic Potential of TYK2 Inhibition in Psoriasis

EP. 5 Therapeutic Potential of TYK2 Inhibition in Psoriasis

EP. 6 Selectivity of TYK2 Inhibition in Psoriasis

EP. 6 Selectivity of TYK2 Inhibition in Psoriasis

EP. 7 Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

EP. 7 Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

EP. 8 Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

EP. 8 Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

EP. 9 Opportunities for TYK2 Inhibition in Moderate Psoriasis

EP. 9 Opportunities for TYK2 Inhibition in Moderate Psoriasis

EP. 10 Other Emerging TYK2 Inhibitors in Psoriasis

EP. 10 Other Emerging TYK2 Inhibitors in Psoriasis

EP. 11 Therapeutic Potential of TYK2 Inhibition in Psoriatic Arthritis

EP. 11 Therapeutic Potential of TYK2 Inhibition in Psoriatic Arthritis

EP. 12 Shared Decision-Making Strategies with TYK2 Inhibition and Future Direction in Psoriasis Care

EP. 12 Shared Decision-Making Strategies with TYK2 Inhibition and Future Direction in Psoriasis Care

Panelists discuss the questions below in this video.

How does the selectivity of TYK2 inhibition differ from JAK inhibition?

At what level of pathway inhibition (% inhibition of IL-12, IL-23, IFN) do we see efficacy without safety liabilities, and how narrow or wide is this therapeutic window compared to JAK inhibitors?

Loss-of-function TYK2 variants have been linked to protection from psoriasis. How do these genetic findings inform our understanding of TYK2’s role and support selective inhibition as a therapeutic strategy?

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