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Spotlight -

This Year In Medicine 2025

Opinion|Videos|December 12, 2025

Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

Author(s)Christopher G. Bunick, MD, PhD, April W. Armstrong, MD, MPH

What are your impressions of the Phase 2b data of zasocitinib in psoriasis, particularly in terms of Psoriasis Area and Severity Index (PASI) responses, dose-dependent effects, and tolerability? How do you see these results influencing your real-world patient selection?

Episodes in this series

EP. 1 Cytokine Pathways and Their Impact on Plaque Psoriasis

EP. 1 Cytokine Pathways and Their Impact on Plaque Psoriasis

EP. 2 Current Standard of Care and Treatment Options in Psoriasis

EP. 2 Current Standard of Care and Treatment Options in Psoriasis

EP. 3 Role of Mechanisms of Action in Treatment Decisions and Personalized Care in Psorias

EP. 3 Role of Mechanisms of Action in Treatment Decisions and Personalized Care in Psorias

EP. 4 Challenges with Current Psoriasis Therapies

EP. 4 Challenges with Current Psoriasis Therapies

EP. 5 Therapeutic Potential of TYK2 Inhibition in Psoriasis

EP. 5 Therapeutic Potential of TYK2 Inhibition in Psoriasis

EP. 6 Selectivity of TYK2 Inhibition in Psoriasis

EP. 6 Selectivity of TYK2 Inhibition in Psoriasis

EP. 7 Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

EP. 7 Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

EP. 8 Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

EP. 8 Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

EP. 9 Opportunities for TYK2 Inhibition in Moderate Psoriasis

EP. 9 Opportunities for TYK2 Inhibition in Moderate Psoriasis

EP. 10 Other Emerging TYK2 Inhibitors in Psoriasis

EP. 10 Other Emerging TYK2 Inhibitors in Psoriasis

EP. 11 Therapeutic Potential of TYK2 Inhibition in Psoriatic Arthritis

EP. 11 Therapeutic Potential of TYK2 Inhibition in Psoriatic Arthritis

EP. 12 Shared Decision-Making Strategies with TYK2 Inhibition and Future Direction in Psoriasis Care

EP. 12 Shared Decision-Making Strategies with TYK2 Inhibition and Future Direction in Psoriasis Care

What are your impressions of the Phase 2b data of zasocitinib in psoriasis, particularly in terms of Psoriasis Area and Severity Index (PASI) responses, dose-dependent effects, and tolerability?

How do you see these results influencing your real-world patient selection?

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