Amassing the Clinical Evidence for Optimized Dyslipidemia Ma - Episode 5
The MD Magazine Peer Exchange “Amassing the Clinical Evidence for Optimized Dyslipidemia Management: Vitamin D, Long-Term Statin Outcomes, and PCSK9 Inhibition” features expert insight and analysis of the latest information on managing hypertension and hyperlipidemia, and in-depth discussion on the use of PCSK9 inhibitors in practice.
This Peer Exchange is moderated by Peter Salgo, MD, professor of medicine and anesthesiology at Columbia University and an associate director of surgical intensive care at the New York-Presbyterian Hospital in New York City.
The panelists are:
Dr. Robinson and the other panelists discuss outcomes from clinical trials that assessed the effect of statin dosage on participants’ LDL levels and debate the definition of “high-intensity” statin therapy.
Researchers conducted three trials of high intensity-statins that show “high-intensity statins reduce events more than moderate-intensity statins. That’s why it’s a 1a recommendation for high-intensity statins in people with clinical cardiovascular disease,” Dr. Robinson said.
Dr. Salgo noted that the focus on statin dose is interesting, because he said his instinct is that if you can get the patient’s LDL levels to the desired target using a smaller statin dose. IF this is the case, he asked “Why go to atorvastatin 80 mg unless you tell me that there’s an additional benefit?”
It’s the LDL level that counted in those studies, not the drug, said Dr. Ballantyne. The recommendations for treatment based on the study data are evidence-based, “but if you actually dig into the details, it ends up you have to use clinical judgment” when prescribing these drugs, he said.