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Spotlight -

This Year In Medicine 2025

Opinion|Videos|September 23, 2024

Long-term Safety of JAK Inhibitors in Atopic Dermatitis

Author(s)Christopher G. Bunick, MD, PhD, Lindsay S. Ackerman, MD, FAAD, Jonathan Silverberg, MD, PhD, MPH

Key Takeaways

Long-term upadacitinib data reveal sustained efficacy and safety, offering insights beyond short-term studies for atopic dermatitis management.
Comparisons with other JAK inhibitors highlight differences in long-term outcomes, influencing clinical decision-making.
Long-term data provide a comprehensive view of treatment benefits and risks, guiding the use of JAKi in extended management of atopic dermatitis.

SHOW MORE

Following a review of findings from the LEVEL UP study, an expert on atopic dermatitis shares what we’ve learned from long-term data on upadacitinib and JAKi.

Episodes in this series

A panel of 3 experts on atopic dermatitis

EP. 1 Heterogenous Presentation of Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 2 Burden of Atopic Dermatitis and its Impact on Patient’s Quality of Life

A panel of 3 experts on atopic dermatitis

EP. 3 Patient’s Goals and Atopic Dermatitis Treatment Selection

A panel of 3 experts on atopic dermatitis

EP. 4 Talking to Patients about Atopic Dermatitis Treatment Response

A panel of 3 experts on atopic dermatitis

EP. 5 Use of PRO in Atopic Dermatitis Clinical Practice

A panel of 3 experts on atopic dermatitis

EP. 6 Incorporating Patient Preferences in the Treatment of Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 7 Changing Standard of Care in Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 8 Unmet Needs and Gaps in AD

A panel of 3 experts on atopic dermatitis

EP. 9 Looking Beyond Type 2 Inflammation in Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 10 JAK Inhibitors in Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 11 Safety Profile of JAK Inhibitors and their Use in Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 12 Monitoring Schedule for JAK Inhibitors in Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 13 Data from LEVEL UP Trial with Upadacitnib in Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 14 Long-term Safety of JAK Inhibitors in Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 15 Use of JAK Inhibitors and Systemic Treatments for Atopic Dermatitis

A panel of 3 experts on atopic dermatitis

EP. 16 Treatment of Bio-Naïve Patients or Those Progressing on Topical or Biologic Atopic Dermatitis Therapy

A panel of 3 experts on atopic dermatitis

EP. 17 Emerging Treatments for Atopic Dermatitis

Video content above is prompted by the following:

Are there any learnings from long-term upadacitinib data that were not seen in short-term data?
What about short vs long-term data with other JAKi?
How do they impact your use of JAKi for atopic dermatitis?

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