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Spotlight -

This Year In Medicine 2025

Opinion|Videos|January 15, 2025

Novel Nonstatin LLTs for Lowering LDL-C and CVD Risk

Author(s)Seth Baum, MD, Erin D. Michos, MD, MHS, Amy Peterson, MD

Key Takeaways

Pediatric lipid screening is vital for early dyslipidemia detection, reducing future cardiovascular disease risk.
Guidelines suggest universal screening at ages 9-11 and 17-21, with selective screening for at-risk children.
Implementation is inconsistent due to barriers like lack of awareness and time constraints in clinical settings.
Strategies to enhance uptake include routine integration, electronic health record reminders, and education for providers and families.

SHOW MORE

Panelists discuss how newer nonstatin therapies, such as PCSK9 inhibitors (inclisiran, alirocumab, evolocumab) and bempedoic acid, offer additional options for LDL-C reduction and cardiovascular risk management.

Episodes in this series

EP. 1 Prevalence of Cardiovascular Disease

EP. 1 Prevalence of Cardiovascular Disease

EP. 2 AHA Guidelines and Patient Mortality

EP. 2 AHA Guidelines and Patient Mortality

EP. 3 Role of LDL-C in ASCVD

EP. 3 Role of LDL-C in ASCVD

EP. 4 Pediatric Lipid Screening

EP. 4 Pediatric Lipid Screening

EP. 5 Lp(a) in Pediatrics

EP. 5 Lp(a) in Pediatrics

EP. 6 DCRM Recommendations for Lipid Testing and LDL-C Management

EP. 6 DCRM Recommendations for Lipid Testing and LDL-C Management

EP. 7 Other Lipid Biomarkers

EP. 7 Other Lipid Biomarkers

EP. 8 LDL-C Management in Subpopulations

EP. 8 LDL-C Management in Subpopulations

EP. 9 Cost Considerations for LDL Reduction Therapies

EP. 9 Cost Considerations for LDL Reduction Therapies

EP. 10 Familial Hypercholesterolemia Testing

EP. 10 Familial Hypercholesterolemia Testing

EP. 11 Role of Lp(a) in ASCVD Risk

EP. 11 Role of Lp(a) in ASCVD Risk

EP. 12 Data Analysis: State of LDL-C Control in Patients With ASCVD

EP. 12 Data Analysis: State of LDL-C Control in Patients With ASCVD

EP. 13 Pediatric Lipid Treatment Recommendations

EP. 13 Pediatric Lipid Treatment Recommendations

EP. 14 International Lipid Expert Panel Recommendations and RACING Trial

EP. 14 International Lipid Expert Panel Recommendations and RACING Trial

EP. 15 SPORT Trial

EP. 15 SPORT Trial

EP. 16 Novel Nonstatin LLTs for Lowering LDL-C and CVD Risk

EP. 16 Novel Nonstatin LLTs for Lowering LDL-C and CVD Risk

EP. 17 CLEAR-Outcomes Data: Primary Prevention With Bempedoic Acid

EP. 17 CLEAR-Outcomes Data: Primary Prevention With Bempedoic Acid

EP. 18 Barriers Associated With Controlling LDL-C

EP. 18 Barriers Associated With Controlling LDL-C

EP. 19 Final Insights

EP. 19 Final Insights

Video content above is prompted by the following:

What are some of the newer, nonstatin LLTs that are approved for lowering LDL-Cand reducing CVD risk (eg, inclisiran, alirocumab, evolocumab, bempedoic acid)?

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