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Spotlight -

This Year In Medicine 2025

Opinion|Videos|December 4, 2024

Role of LDL-C in ASCVD

Author(s)Seth Baum, MD, Erin D. Michos, MD, MHS, Amy Peterson, MD

Key Takeaways

LDL-C is a key contributor to ASCVD by promoting plaque formation in arterial walls.
Lifestyle factors like poor diet, inactivity, and smoking elevate LDL-C levels.
Genetic predispositions, such as familial hypercholesterolemia, significantly impact LDL-C levels.
Effective ASCVD prevention and treatment require understanding both lifestyle and genetic influences on LDL-C.

SHOW MORE

Panelists discuss how elevated LDL-C levels significantly contribute to ASCVD development through both modifiable lifestyle factors and genetic predisposition, making it a critical target for cardiovascular disease prevention.

Episodes in this series

EP. 1 Prevalence of Cardiovascular Disease

EP. 1 Prevalence of Cardiovascular Disease

EP. 2 AHA Guidelines and Patient Mortality

EP. 2 AHA Guidelines and Patient Mortality

EP. 3 Role of LDL-C in ASCVD

EP. 3 Role of LDL-C in ASCVD

EP. 4 Pediatric Lipid Screening

EP. 4 Pediatric Lipid Screening

EP. 5 Lp(a) in Pediatrics

EP. 5 Lp(a) in Pediatrics

EP. 6 DCRM Recommendations for Lipid Testing and LDL-C Management

EP. 6 DCRM Recommendations for Lipid Testing and LDL-C Management

EP. 7 Other Lipid Biomarkers

EP. 7 Other Lipid Biomarkers

EP. 8 LDL-C Management in Subpopulations

EP. 8 LDL-C Management in Subpopulations

EP. 9 Cost Considerations for LDL Reduction Therapies

EP. 9 Cost Considerations for LDL Reduction Therapies

EP. 10 Familial Hypercholesterolemia Testing

EP. 10 Familial Hypercholesterolemia Testing

EP. 11 Role of Lp(a) in ASCVD Risk

EP. 11 Role of Lp(a) in ASCVD Risk

EP. 12 Data Analysis: State of LDL-C Control in Patients With ASCVD

EP. 12 Data Analysis: State of LDL-C Control in Patients With ASCVD

EP. 13 Pediatric Lipid Treatment Recommendations

EP. 13 Pediatric Lipid Treatment Recommendations

EP. 14 International Lipid Expert Panel Recommendations and RACING Trial

EP. 14 International Lipid Expert Panel Recommendations and RACING Trial

EP. 15 SPORT Trial

EP. 15 SPORT Trial

EP. 16 Novel Nonstatin LLTs for Lowering LDL-C and CVD Risk

EP. 16 Novel Nonstatin LLTs for Lowering LDL-C and CVD Risk

EP. 17 CLEAR-Outcomes Data: Primary Prevention With Bempedoic Acid

EP. 17 CLEAR-Outcomes Data: Primary Prevention With Bempedoic Acid

EP. 18 Barriers Associated With Controlling LDL-C

EP. 18 Barriers Associated With Controlling LDL-C

EP. 19 Final Insights

EP. 19 Final Insights

Video content above is prompted by the following:

What role does low-density lipoprotein-C (LDL-C) play in ASCVD?
What lifestyle and genetic factors contribute to developing high blood levels of LDL-C?

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Gus Alva, MD, DFAPA; Ilan Melnick, MD

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