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Spotlight -

This Year In Medicine 2025

Opinion|Videos|September 9, 2024

Oral JAK inhibitors and Their Use for Treatment of Atopic Dermatitis

Author(s)Raj Chovatiya, MD, PhD, George Han, MD, PhD, Elizabeth Swanson, MD

Medical experts review the FDA-approved oral JAK inhibitors for atopic dermatitis (abrocitinib, upadacitinib), highlighting differences from conventional therapies, their appeal, and the criteria for recommending them based on disease severity and patient characteristics.

Episodes in this series

EP. 1 JAK Inhibitors and Pathophysiology of Atopic Dermatitis

EP. 1 JAK Inhibitors and Pathophysiology of Atopic Dermatitis

EP. 2 Oral JAK inhibitors and Their Use for Treatment of Atopic Dermatitis

EP. 2 Oral JAK inhibitors and Their Use for Treatment of Atopic Dermatitis

EP. 3 Oral JAK Inhibitor Use in Atopic Dermatitis: Screening and Monitoring Patients

EP. 3 Oral JAK Inhibitor Use in Atopic Dermatitis: Screening and Monitoring Patients

EP. 4 Long-term Safety Data for JAK Inhibitors in Atopic Dermatitis

EP. 4 Long-term Safety Data for JAK Inhibitors in Atopic Dermatitis

EP. 5 Utilizing Long-Term Atopic Dermatitis Data in Clinical Practice

EP. 5 Utilizing Long-Term Atopic Dermatitis Data in Clinical Practice

EP. 6 Data on Early Itch Relief with JAK Inhibitors in Atopic Dermatitis

EP. 6 Data on Early Itch Relief with JAK Inhibitors in Atopic Dermatitis

EP. 7 Speed of Itch Relief in Atopic Dermatitis

EP. 7 Speed of Itch Relief in Atopic Dermatitis

EP. 8 Systemic Treatments and Switching Therapy in Atopic Dermatitis

EP. 8 Systemic Treatments and Switching Therapy in Atopic Dermatitis

EP. 9 Treatment Expectations and Patient Conversations in Atopic Dermatitis

EP. 9 Treatment Expectations and Patient Conversations in Atopic Dermatitis

EP. 10 Switching from Biologics to JAK Inhibitors in Atopic Dermatitis: Clinical Data

EP. 10 Switching from Biologics to JAK Inhibitors in Atopic Dermatitis: Clinical Data

EP. 11 Treatment Breaks and Rescue Treatments in Atopic Dermatitis

EP. 11 Treatment Breaks and Rescue Treatments in Atopic Dermatitis

EP. 12 Switching patients to JAK Inhibitors in Atopic Dermatitis in Clinical Practice

EP. 12 Switching patients to JAK Inhibitors in Atopic Dermatitis in Clinical Practice

EP. 13 Treatment Flexibility While on Abrocitinib in Atopic Dermatitis (JADE REGIMEN)

EP. 13 Treatment Flexibility While on Abrocitinib in Atopic Dermatitis (JADE REGIMEN)

EP. 14 Future Outlook for Atopic Dermatitis Treatments

EP. 14 Future Outlook for Atopic Dermatitis Treatments

Video content above is prompted by the following:

Please review oral JAK inhibitors that are FDA approved for atopic dermatitis (AD) (abrocitinib, upadacitinib).
Are there any differences in the mechanism of action of FDA-approved JAK inhibitors compared with conventional therapies that are important for prescribers to know?
Why is treatment with oral JAK inhibitors an attractive option for AD?
At what point during a patient’s treatment journey would you recommend use of JAK inhibitors?
How does disease severity affect your recommendation?
In which patients would you consider using a JAK inhibitor? Please describe characteristics of an ideal patient for oral JAK inhibitor.

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