February brought significant developments in psychiatry, spanning antidepressant use during pregnancy to headache-related suicide risk, and new data on treatment-resistant depression (TRD). A new investigation revealed a nearly 50% drop in antidepressant prescriptions during pregnancy without a compensatory rise in psychotherapy and a Danish cohort study identified a troubling link between headache diagnoses and increased suicide risk. On the drug development front, hopes for SPN-820 as a novel treatment for TRD were tempered after a Phase 2b trial failed to show significant symptom improvement.
